Hak David J
Orthopedic Surgery Denver Health/University of Colorado, 777 Bannock Street MC 0188, Denver, CO 80204 USA.
Injury. 2018 Aug;49(8):1461-1465. doi: 10.1016/j.injury.2018.04.016. Epub 2018 Apr 20.
Compromised bone strength in osteoporosis predisposes patients to an increased fracture risk. The management of these fractures is complicated due to the poor bone quality, which may lead to inadequate fixation strength and stability. While a number of studies using osteoporotic animal models have shown a detrimental impact on fracture healing, clinical evidence regarding whether fracture healing is impaired in the presence of osteoporosis is complicated by numerous associated conditions including advancing age. The mechanism of some anti-osteoporotic medications creates concern about a potential detrimental impact on fracture healing, while others appear to enhance fracture healing. The current evidence indicates that the beneficial effects of anti-osteoporosis treatment exceeds any concerns about possible adverse consequences on fracture healing in most circumstances.
骨质疏松症患者骨强度受损，使其骨折风险增加。由于骨质较差，这些骨折的治疗较为复杂，这可能导致固定强度和稳定性不足。虽然一些使用骨质疏松动物模型的研究表明对骨折愈合有不利影响，但关于骨质疏松症是否会损害骨折愈合的临床证据因包括年龄增长在内的众多相关情况而变得复杂。一些抗骨质疏松药物的作用机制引发了对其可能对骨折愈合产生潜在不利影响的担忧，而另一些药物似乎能促进骨折愈合。目前的证据表明，在大多数情况下，抗骨质疏松治疗的益处超过了对其可能对骨折愈合产生的不良后果的任何担忧。
