Does reduced zona pellucida binding protein 2 (ZPBP2) expression on chromosome 17q21 protect against asthma?
作者信息
Miller Marina, Vuong Christine, Garcia Meghan Farrell, Rosenthal Peter, Das Sudipta, Weng Ning, Pham Alexa, Kim Yu Jin, Broide David H
机构信息
Department of Medicine, University of California San Diego, La Jolla, Calif.
Department of Medicine, University of California San Diego, La Jolla, Calif.
出版信息
J Allergy Clin Immunol. 2018 Aug;142(2):706-709.e4. doi: 10.1016/j.jaci.2018.04.011. Epub 2018 Apr 28.
Abstract
摘要
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Does reduced zona pellucida binding protein 2 (ZPBP2) expression on chromosome 17q21 protect against asthma?17号染色体q21区域上透明带结合蛋白2（ZPBP2）表达降低是否能预防哮喘？
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Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines.遗传和表观遗传变异的相互作用决定了淋巴母细胞系中哮喘相关位点 17q12-q21 的基因表达模式。
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Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.与哮喘和自身免疫性疾病风险相关的ZPBP2/GSDMB/ORMDL3基因座中的等位基因特异性染色质重塑。
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本文引用的文献
1
Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca oscillations in asthma.奥罗莫昔单抗样蛋白 3（ORMDL3）上调哮喘气道平滑肌增殖、收缩和钙振荡。
J Allergy Clin Immunol. 2018 Jul;142(1):207-218.e6. doi: 10.1016/j.jaci.2017.08.015. Epub 2017 Sep 7.
2
Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases.染色体 17q21 基因 ORMDL3 和 GSDMB 在哮喘和免疫性疾病中的作用。
Adv Immunol. 2017;135:1-52. doi: 10.1016/bs.ai.2017.06.001. Epub 2017 Jul 19.
3
Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.前沿：靶向上皮细胞中的ORMDL3会增加而非降低气道反应性，并与鞘氨醇-1-磷酸水平升高有关。
J Immunol. 2017 Apr 15;198(8):3017-3022. doi: 10.4049/jimmunol.1601848. Epub 2017 Mar 8.
4
Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide.类oroscomucoid蛋白3（ORMDL3）转基因小鼠的鞘脂水平降低，包括鞘氨醇-1-磷酸和神经酰胺。
J Allergy Clin Immunol. 2017 Apr;139(4):1373-1376.e4. doi: 10.1016/j.jaci.2016.08.053. Epub 2016 Nov 5.
5
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.Gasdermin B（GSDMB）诱导出一种哮喘表型，其特征为气道反应性增加和重塑，而无肺部炎症。
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13132-13137. doi: 10.1073/pnas.1610433113. Epub 2016 Oct 31.
6
Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.肺部ORMDL3对于链格孢属诱导的过敏性气道疾病的诱导至关重要。
J Allergy Clin Immunol. 2017 May;139(5):1496-1507.e3. doi: 10.1016/j.jaci.2016.07.033. Epub 2016 Sep 10.
7
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.ORMDL3 转基因小鼠表现出气道重塑和气道高反应性，这些特征类似于哮喘。
J Immunol. 2014 Apr 15;192(8):3475-87. doi: 10.4049/jimmunol.1303047. Epub 2014 Mar 12.
8
ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.ORMDL3 是一种诱导性肺上皮基因，调节金属蛋白酶、趋化因子、OAS 和 ATF6。
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16648-53. doi: 10.1073/pnas.1204151109. Epub 2012 Sep 24.
9
Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis.顶体基质中透明带结合蛋白的缺失会破坏顶体生物发生和精子形态发生。
Mol Cell Biol. 2007 Oct;27(19):6794-805. doi: 10.1128/MCB.01029-07. Epub 2007 Jul 30.
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