将肽等排体引入对映选择性肽基催化剂作为机理探针。
Incorporation of Peptide Isosteres into Enantioselective Peptide-Based Catalysts as Mechanistic Probes.
作者信息
Vasbinder Melissa M, Jarvo Elizabeth R, Miller Scott J
机构信息
Department of Chemistry, Boston College Chestnut Hill, MA 02467-3860 (USA) Fax: (+1) 617-552-3620.
出版信息
Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2824-2827. doi: 10.1002/1521-3773(20010803)40:15<2824::AID-ANIE2824>3.0.CO;2-J.
Abstract
Olefinic analogues of effective peptide-based catalysts for the kinetic resolution of functionalized racemic secondary alcohols have been synthesized. The isosteric replacement of the peptide amide bond in 1 with an (E)-alkene to form 2 has enabled the evaluation of the kinetic role of particular amides within these catalysts.
摘要
已合成用于官能化外消旋仲醇动力学拆分的有效肽基催化剂的烯烃类似物。用（E）-烯烃对1中的肽酰胺键进行等排取代以形成2，从而能够评估这些催化剂中特定酰胺的动力学作用。
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