Marshall Lindsey, Girardot Fabrice, Demeneix Barbara A, Coen Laurent
Evolution des Régulations Endocriniennes, Département Adaptation du vivant, UMR CNRS 7221, Muséum National d'Histoire Naturelle, Sorbonne Université, Paris, France.
Cell Biosci. 2018 Apr 19;8:31. doi: 10.1186/s13578-018-0231-5. eCollection 2018.
We recently used an endoscopy-based resection method to explore the consequences of cardiac injury in adult , obtaining the result that the adult heart is unable to regenerate. At 11 months post-amputation, cellular and biological marks of scarring persisted. We thus concluded that, contrary to urodeles and teleosts, adult anurans share a cardiac injury outcome similar to adult mammals. However, in their work published in this journal on the 13 December 2017, Liao et al. showed that the adult heart is capable of efficient, almost scar free regeneration, a result at odds with our previous observation. These findings contrast with and challenge the outcome of adult heart repair following injury in species. Here we discuss the question of the intrinsic cardiac regenerative properties of an adult heart in anuran amphibians.
我们最近采用了一种基于内窥镜的切除方法来探究成年动物心脏损伤的后果,结果发现成年动物的心脏无法再生。截肢后11个月,瘢痕形成的细胞和生物学标记依然存在。因此我们得出结论,与有尾目和硬骨鱼不同,成年无尾目动物的心脏损伤结果与成年哺乳动物相似。然而,廖等人在2017年12月13日发表于本期刊的研究中表明,成年动物的心脏能够高效再生,几乎不留瘢痕,这一结果与我们之前的观察结果相悖。这些发现与其他物种成年心脏损伤修复的结果形成对比,并对其提出了挑战。在此,我们讨论成年无尾两栖动物心脏的内在再生特性问题。