Christensen Regitse Højgaard, Wedell-Neergaard Anne-Sophie, Lehrskov Louise Lang, Legård Grit Elster, Dorph Emma Berndt, Nymand Stine, Ball Maria Korf, Zacho Morten, Christensen Robin, Ellingsgaard Helga, Rosenmeier Jaya Birgitte, Krogh-Madsen Rikke, Pedersen Bente Klarlund, Karstoft Kristian
The Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, F, Copenhagen, Denmark.
Trials. 2018 May 2;19(1):266. doi: 10.1186/s13063-018-2637-0.
Exercise reduces the amount of visceral adipose tissue (VAT) and the risk of cardiometabolic diseases. The underlying mechanisms responsible for these exercise-induced adaptations are unclear, but they may involve lipolytic actions of interleukin-6 (IL-6). Contracting skeletal muscles secrete IL-6, leading to increased circulating IL-6 levels in response to exercise. The aim of this study is to investigate whether IL-6 is involved in mediating the effects of exercise on visceral and epicardial adipose tissue volume and glycaemic control.
METHODS/DESIGN: Seventy-five physically inactive males and females aged > 18 years with a waist-to-height ratio > 0.5 and/or waist circumference ≥ 88 cm (females) or ≥ 102 cm (males) are being recruited to participate in a 12-week intervention study. Participants are randomly allocated to one of five groups (1:1:1:1:1). Two groups consist of supervised endurance exercise training combined with the IL-6 blocker tocilizumab (ET) or saline used as placebo (EP), two groups consist of no exercise combined with tocilizumab (NT) or placebo (NP), and one group consists of resistance exercise and placebo (RP). Although the study is an exploratory trial, the primary outcome is change in VAT volume from before to after intervention, with secondary outcomes being changes in (1) epicardial adipose tissue, (2) pericardial adipose tissue and (3) gastric emptying. Depots of adipose tissue are quantitated by magnetic resonance imaging Gastric emptying and glucose metabolism are assessed using mixed-meal tolerance tests.
Understanding the role of IL-6 in mediating the effects of exercise on visceral and epicardial adipose tissue and glycaemic control may lead to novel therapeutic approaches in the prevention of cardiometabolic diseases.
ClinicalTrials.gov, NCT02901496 . Registered on 1 August 2016 and posted retrospectively on 15 September 2016.
运动可减少内脏脂肪组织（VAT）的量以及心脏代谢疾病的风险。导致这些运动诱导适应性变化的潜在机制尚不清楚，但可能涉及白细胞介素-6（IL-6）的脂解作用。收缩的骨骼肌会分泌IL-6，导致运动时循环中的IL-6水平升高。本研究的目的是调查IL-6是否参与介导运动对内脏和心外膜脂肪组织体积以及血糖控制的影响。
方法/设计：正在招募75名年龄大于18岁、腰高比大于0.5和/或腰围≥88厘米（女性）或≥102厘米（男性）的缺乏体育锻炼的男性和女性，参与一项为期12周的干预研究。参与者被随机分配到五组之一（1:1:1:1:1）。两组包括有监督的耐力运动训练，联合IL-6阻断剂托珠单抗（ET）或用作安慰剂的生理盐水（EP）；两组包括不运动联合托珠单抗（NT）或安慰剂（NP）；一组包括抗阻运动和安慰剂（RP）。尽管该研究是一项探索性试验，但其主要结局是干预前后VAT体积的变化，次要结局包括：（1）心外膜脂肪组织、（2）心包脂肪组织和（3）胃排空的变化。脂肪组织库通过磁共振成像进行定量。胃排空和葡萄糖代谢使用混合餐耐量试验进行评估。
了解IL-6在介导运动对内脏和心外膜脂肪组织以及血糖控制的影响中的作用，可能会为预防心脏代谢疾病带来新的治疗方法。
ClinicalTrials.gov，NCT02901496。于2016年8月1日注册，并于2016年9月15日追溯发布。
