Bay Marie Lund, Pedersen Bente Klarlund
Centre of Inflammation and Metabolism/Centre for Physical Activity Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Front Physiol. 2020 Sep 9;11:567881. doi: 10.3389/fphys.2020.567881. eCollection 2020.
Skeletal muscle secretes several hundred myokines that facilitate communication from muscle to other organs, such as, adipose tissue, pancreas, liver, gut, and brain. The biological roles of myokines include effects on e.g., memory and learning, as well as glucose and lipid metabolism. The present minireview focuses on recent developments showing that exercise-induced myokines are involved in immunometabolism of importance for the control of e.g., tumor growth and chronic inflammation. In this review, immunometabolism is discussed as the non-immune related pathologies leading to an immune response and some degree of inflammation, which promotes metabolic abnormalities.
骨骼肌分泌数百种肌动蛋白，这些肌动蛋白有助于从肌肉到其他器官的通讯，如脂肪组织、胰腺、肝脏、肠道和大脑。肌动蛋白的生物学作用包括对记忆和学习以及葡萄糖和脂质代谢等方面的影响。本微型综述重点关注最近的研究进展，这些进展表明运动诱导的肌动蛋白参与了对控制肿瘤生长和慢性炎症等具有重要意义的免疫代谢过程。在本综述中，免疫代谢被讨论为导致免疫反应和一定程度炎症从而促进代谢异常的非免疫相关病理状态。
