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在印度尼西亚健康年轻男性成年人中,体重、体脂百分比和内脏脂肪水平比腰围和体重指数更能预测胰岛素抵抗。

Body Mass, Total Body Fat Percentage, and Visceral Fat Level Predict Insulin Resistance Better Than Waist Circumference and Body Mass Index in Healthy Young Male Adults in Indonesia.

作者信息

Kurniawan Liong Boy, Bahrun Uleng, Hatta Mochammad, Arif Mansyur

机构信息

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia.

Department of Immunology and Biomolecular, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia.

出版信息

J Clin Med. 2018 May 1;7(5):96. doi: 10.3390/jcm7050096.

Abstract

The incidence of obesity which leads to insulin resistance (IR) and metabolic disorder is increasing in developing countries, including Indonesia. Male adults have a higher risk of abdominal obesity than females. This is associated with cardiometabolic disorders. Several anthropometric measurements have been proposed to predict IR. The aim of this study was to investigate whether body mass, body mass index (BMI), waist circumference (WC), body fat percentage (BF) or visceral fat level (VF) could become a better predictor of IR in healthy young male adults. A total of 140 healthy young male adults ranging from 18⁻25 years were recruited in the study. Insulin resistance was measured by calculating their Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Subjects with a HOMA-IR value ≥75th percentile, with cut off 3.75, were defined as IR. Anthropometric measurements including body weight, BMI, and WC were performed, whereas BF and VC were measured using bioelectrical impedance analysis (BIA). IR had a strong correlation with body weight, BMI, WC, BF, and VF. In the area under the curve of body mass, BF and VF were slightly greater than WC and BMI. Anthropometric measurements correlated strongly with IR but body weight, BF, VF had a stronger correlation than WC and BMI in healthy young male adults.

摘要

在包括印度尼西亚在内的发展中国家,导致胰岛素抵抗(IR)和代谢紊乱的肥胖发生率正在上升。成年男性腹部肥胖的风险高于女性。这与心脏代谢紊乱有关。已经提出了几种人体测量方法来预测胰岛素抵抗。本研究的目的是调查体重、体重指数(BMI)、腰围(WC)、体脂百分比(BF)或内脏脂肪水平(VF)是否能成为健康年轻男性成年人胰岛素抵抗的更好预测指标。本研究共招募了140名年龄在18至25岁之间的健康年轻男性成年人。通过计算他们的胰岛素抵抗稳态模型评估(HOMA-IR)来测量胰岛素抵抗。HOMA-IR值≥第75百分位数(临界值为3.75)的受试者被定义为胰岛素抵抗。进行了包括体重、BMI和WC在内的人体测量,而BF和VC则使用生物电阻抗分析(BIA)进行测量。胰岛素抵抗与体重、BMI、WC、BF和VF有很强的相关性。在体重、BF和VF的曲线下面积方面,略大于WC和BMI。人体测量与胰岛素抵抗密切相关,但在健康年轻男性成年人中,体重、BF、VF的相关性比WC和BMI更强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb32/5977135/173644f1c179/jcm-07-00096-g001.jpg

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