Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, China.
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, China.
Cell Death Dis. 2018 May 1;9(5):509. doi: 10.1038/s41419-018-0556-3.
HOXB9, as a HOX family transcription factor, playing a significant role in embryonic development and cancer progression. However, the function of HOXB9 and its precise mechanism in regulating endometrial cancer progression remains unknown. Here, we demonstrated that the expression of HOXB9 was increased in endometrial cancer, and associated with histological grade and lymph node metastasis. In addition, elevated HOXB9 predicts a poor prognosis in endometrial cancer patients. Interestingly, bioinformatics analysis of TCGA cancer database showed that HOXB9 expression is positively correlated with E2F3 expression. Moreover, HOXB9 promoted E2F3 expression by directly targeting to its promoter. Furthermore, we found that knocking down E2F3 abolished the ability of HOXB9 in enhancing cell migration. Taken together, for the first, we demonstrated the function and mechanism of HOXB9 in regulating endometrial cancer progression, and indicated HOXB9 may be a novel prognostic marker of endometrial cancer.
HOXB9 作为 HOX 家族转录因子，在胚胎发育和癌症进展中发挥重要作用。然而，HOXB9 的功能及其在调节子宫内膜癌进展中的精确机制尚不清楚。在这里，我们证明 HOXB9 的表达在子宫内膜癌中增加，并与组织学分级和淋巴结转移相关。此外，HOXB9 的高表达预示着子宫内膜癌患者的预后不良。有趣的是，TCGA 癌症数据库的生物信息学分析表明，HOXB9 的表达与 E2F3 的表达呈正相关。此外，HOXB9 通过直接靶向其启动子促进 E2F3 的表达。此外，我们发现敲低 E2F3 可消除 HOXB9 增强细胞迁移的能力。总之，我们首次证明了 HOXB9 在调节子宫内膜癌进展中的功能和机制，并表明 HOXB9 可能是子宫内膜癌的一个新的预后标志物。
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