ProLego：用于提取和可视化蛋白质结构中拓扑模块的工具。
ProLego: tool for extracting and visualizing topological modules in protein structures.
机构信息
School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
出版信息
BMC Bioinformatics. 2018 May 4;19(1):167. doi: 10.1186/s12859-018-2171-9.
BACKGROUND
In protein design, correct use of topology is among the initial and most critical feature. Meticulous selection of backbone topology aids in drastically reducing the structure search space. With ProLego, we present a server application to explore the component aspect of protein structures and provide an intuitive and efficient way to scan the protein topology space.
RESULT
We have implemented in-house developed "topological representation" in an automated-pipeline to extract protein topology from given protein structure. Using the topology string, ProLego, compares topology against a non-redundant extensive topology database (ProLegoDB) as well as extracts constituent topological modules. The platform offers interactive topology visualization graphs.
CONCLUSION
ProLego, provides an alternative but comprehensive way to scan and visualize protein topology along with an extensive database of protein topology. ProLego can be found at http://www.proteinlego.com.
背景
在蛋白质设计中，正确使用拓扑结构是最初和最关键的特征之一。精心选择骨架拓扑结构有助于大幅缩小结构搜索空间。我们使用 ProLego 提供了一个服务器应用程序来探索蛋白质结构的组件方面，并提供了一种直观高效的方法来扫描蛋白质拓扑空间。
结果
我们在内部开发的“拓扑表示”的自动化管道中实现了从给定蛋白质结构中提取蛋白质拓扑结构的功能。使用拓扑字符串，ProLego 将拓扑结构与非冗余的广泛拓扑数据库（ProLegoDB）进行比较，同时提取组成拓扑模块。该平台提供了交互式拓扑可视化图。
结论
ProLego 提供了一种替代但全面的方法来扫描和可视化蛋白质拓扑结构，同时提供了广泛的蛋白质拓扑数据库。可以在 http://www.proteinlego.com 找到 ProLego。
Zotero 插件