Centre for Climate and Air Pollution Studies, School of Physics and the Ryan Institute, National University of Ireland, University Road, Galway H91 CF50, Ireland.
Centre for Climate and Air Pollution Studies, School of Physics and the Ryan Institute, National University of Ireland, University Road, Galway H91 CF50, Ireland.
Environ Res. 2018 Aug;165:235-236. doi: 10.1016/j.envres.2018.04.025. Epub 2018 May 3.
Glyphosate is the highest volume herbicide used globally and has recently been classified as a 2 A 'probably carcinogenic to humans' by the International Agency for Research on Cancer (IARC). There is limited data to evaluate the public health impacts from glyphosate exposure. The objective of this study is to conduct an exploratory glyphosate exposure assessment study among Irish adults, who were non-occupational users of glyphosate.
A convenient sampling method was used, collecting one first morning void spot urine sample from each participant.
A biomonitoring survey involving the collection and analysis of 20 ml spot urine samples from 50 Irish adults was conducted in June 2017. Participants completed a short questionnaire to collect information on demographics, dietary habits and lifestyle. Glyphosate was extracted using solid phase extraction (SPE) and analysed by liquid chromatography tandem mass spectrometry (LC-MC/MS).
Of the 50 urine samples analysed, 10 (20%) contained detectable levels of glyphosate (0.80-1.35 µg L). Exposure concentrations are higher than those reported in comparable studies of European and American adults.
Glyphosate was detectable in 20% of the samples collected from Irish adults. The low proportion of detectable glyphosate levels could be due to lower localised use of pesticides, having a small sample size or the higher analytical detection limit used in this study (0.5 µg L), which could underestimate the true exposure and warrants further investigation. Given the widespread use of glyphosate, further information on population exposure is required to advance our understanding of the relationship between chronic low dose exposure to glyphosate and human health risk.
草甘膦是全球使用量最大的除草剂，最近被国际癌症研究机构（IARC）归类为 2A 类“可能对人类致癌”物质。目前评估草甘膦暴露对公众健康影响的数据有限。本研究旨在对爱尔兰非职业性使用草甘膦的成年人进行草甘膦暴露评估研究。
采用方便抽样法，从每位参与者采集一份晨尿斑片尿液样本。
2017 年 6 月进行了一项涉及 50 名爱尔兰成年人采集和分析 20ml 斑片尿液样本的生物监测调查。参与者完成了一份简短的问卷，收集有关人口统计学、饮食习惯和生活方式的信息。草甘膦采用固相萃取（SPE）提取，用液相色谱串联质谱（LC-MC/MS）分析。
在所分析的 50 份尿液样本中，有 10 份（20%）含有可检测水平的草甘膦（0.80-1.35µg/L）。暴露浓度高于欧洲和美国成年人可比研究报告的浓度。
从爱尔兰成年人采集的样本中，有 20%可检测到草甘膦。可检测到草甘膦的比例较低可能是由于当地农药使用较少、样本量较小，或者本研究中使用的分析检测限较高（0.5µg/L），这可能低估了真实暴露水平，需要进一步调查。鉴于草甘膦的广泛使用，需要进一步了解人群暴露情况，以增进我们对慢性低剂量暴露于草甘膦与人类健康风险之间关系的理解。
