环状 RNA 在人类疾病中的作用机制。
The mechanism and function of circular RNAs in human diseases.
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xiangya Stomatological Hospital, Central South University, Changsha, China.
出版信息
Exp Cell Res. 2018 Jul 15;368(2):147-158. doi: 10.1016/j.yexcr.2018.05.002. Epub 2018 May 3.
Circular RNAs (circRNAs) are a recently discovered form of RNA. Initially, circRNAs were believed to result from errors during the process of gene transcription. However, after further investigation, scientists suggested that circRNAs are of great biological significance. CircRNAs show stability, conservation, abundance, and tissue and stage specificity. They can also function as miRNA sponges, regulate gene expression, and interact with proteins to affect cell behavior. Emerging evidence has also demonstrated that circRNAs participate or show abnormal expression in diseases, including central nervous system diseases, cardiovascular diseases and cancers, indicating their marked potential in the prediction and prognosis of diseases and clinical treatment.
环状 RNA（circRNAs）是一种新发现的 RNA 形式。最初，circRNAs 被认为是基因转录过程中产生的错误。然而，经过进一步研究，科学家们提出 circRNAs 具有重要的生物学意义。circRNAs 表现出稳定性、保守性、丰度以及组织和阶段特异性。它们还可以作为 miRNA 的海绵，调节基因表达，并与蛋白质相互作用，影响细胞行为。新兴的证据还表明，circRNAs 参与或在疾病中表现出异常表达，包括中枢神经系统疾病、心血管疾病和癌症，这表明它们在疾病的预测和预后以及临床治疗中有显著的潜力。
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