Faculty of Pharmacy, Department of Analytical Chemistry, Nutrition and Food Science, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Anal Bioanal Chem. 2018 Jun;410(16):3789-3803. doi: 10.1007/s00216-018-1058-y. Epub 2018 May 7.
Plastic materials are widely used in food packaging applications; however, there is increased concern because of the possible release of undesirable components into foodstuffs. Migration of plastic constituents not only has the potential to affect product quality but also constitutes a risk to consumer health. In order to check the safety of food contact materials, analytical methodologies to identify potential migrants are required. In the first part of this work, a GC/MS screening method was developed for the identification of components from plastic packaging materials including intentionally and "non-intentionally added substances" (NIAS) as potential migrants. In the second part of this study, the presence of seven compounds (bis (2-ethylhexyl) phthalate (DEHP), diethyl phthalate (DEP), diisobutyl phthalate (DIBP), dibutyl phthalate (DBP), butylated hydroxytoluene (BHT), acetyl tributyl citrate (ATBC), benzophenone (BP)) previously identified in packaging materials were investigated in food products (corn and potatoes snacks, cookies, and cakes). For this purpose, a suitable extraction method was developed and quantification was performed using GC-MS. The developed method was validated in terms of linearity, recovery, repeatability, and limits of detection and quantification. The spiked recoveries varied between 82.7 and 116.1%, and relative standard deviation (RSD) was in the range of 2.22-15.9%. The plasticizer ATBC was the most detected compound (94% samples), followed by DEP (65%), DEHP (47%), BP (44%), DBP (35%), DIBP (21%), and BHT (12%). Regarding phthalates, DEP and DEHP were the most frequently detected compounds in concentrations up to 1.44 μg g. In some samples, only DBP exceeded the European SML of 0.3 mg kg established in Regulation 10/2011. Graphical abstract Chemical migration from plastic packaging into food.
塑料材料广泛应用于食品包装领域；然而，由于可能有不合规成分释放到食品中，人们对此愈发担忧。塑料成分的迁移不仅有可能影响产品质量，还对消费者健康构成风险。为了检查食品接触材料的安全性，需要采用分析方法来识别潜在的迁移物。在这项工作的第一部分中，开发了一种 GC/MS 筛选方法，用于识别塑料包装材料中的成分，包括有意和“非故意添加物质”（NIAS）作为潜在的迁移物。在本研究的第二部分中，研究了在食品产品（玉米和土豆零食、饼干和蛋糕）中先前在包装材料中发现的七种化合物（邻苯二甲酸二（2-乙基己基）酯（DEHP）、邻苯二甲酸二乙酯（DEP）、邻苯二甲酸二异丁酯（DIBP）、邻苯二甲酸二丁酯（DBP）、丁基化羟基甲苯（BHT）、乙酰基三丁酸酯（ATBC）、二苯甲酮（BP））的存在情况。为此，开发了一种合适的提取方法，并使用 GC-MS 进行定量分析。该方法在线性、回收率、重复性和检测限和定量限方面进行了验证。加标回收率在 82.7%至 116.1%之间，相对标准偏差（RSD）在 2.22%至 15.9%之间。增塑剂 ATBC 是检测到的最常见化合物（94%的样品），其次是 DEP（65%）、DEHP（47%）、BP（44%）、DBP（35%）、DIBP（21%）和 BHT（12%）。关于邻苯二甲酸酯，DEP 和 DEHP 是在浓度高达 1.44μg/g 时最常被检测到的化合物。在一些样品中，只有 DBP 超过了欧盟法规 10/2011 规定的 0.3mg/kg 的 SML。
