Hokkaido Research Center, Forestry and Forest Products Research Institute (FFPRI), Forest Research and Management Organization, 7 Hitsujigaoka, Sapporo, Hokkaido 062-8516, Japan; Research Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Sapporo, Hokkaido 060-8589, Japan.
Hokkaido Research Center, Forestry and Forest Products Research Institute (FFPRI), Forest Research and Management Organization, 7 Hitsujigaoka, Sapporo, Hokkaido 062-8516, Japan.
Environ Res. 2018 Aug;165:274-278. doi: 10.1016/j.envres.2018.04.034. Epub 2018 May 7.
It has long been debated whether a little stress may be "good" for you. Extensive evidence has now sufficiently accumulated demonstrating that low doses of a vast range of chemical and physical agents induce protective/beneficial effects while the opposite occurs at higher doses, a phenomenon known as hormesis. Low doses of environmental agents have recently induced autophagy, a critical adaptive response that protects essentially all cell types, as well as being transgenerational via epigenetic mechanisms. These collective findings highlight a generalized and substantial ongoing dose-response transformation with significant implications for disease biology and clinical applications, challenging the history and practice of toxicology and pharmacology along with an appeal to stake holders to reexamine the process of risk assessment, with the goal of optimizing public health rather than simply avoiding harm.
长期以来，人们一直在争论一点压力是否对你有好处。现在已经积累了大量的证据，证明大量的化学和物理制剂的低剂量会产生保护/有益的效果，而高剂量则会产生相反的效果，这种现象被称为适应原性。最近，环境制剂的低剂量诱导了自噬，这是一种关键的适应性反应，可以保护几乎所有的细胞类型，并且通过表观遗传机制进行跨代传递。这些综合发现强调了一种普遍存在的、实质性的剂量反应转换，这对疾病生物学和临床应用具有重要意义，挑战了毒理学和药理学的历史和实践，并呼吁利益相关者重新审视风险评估过程，目标是优化公共健康，而不仅仅是避免伤害。
