Potel G, Touze M D, Baron D
Laboratoire d'Antibiologie expérimentale et clinique, Faculté de Médecine, Nantes.
Presse Med. 1988 Oct 26;17(37):1981-4.
Probability antibiotic treatments are based on two "best guesses": the nature of the responsible organism and its resistance phenotype. Such treatments are justified in immunocompetent patients with severe infection. The microbiological and pharmacokinetic properties of third generation cephalosporins, and notably ceftazidime, are such that their use as single or combined therapy can be determined. A very wide spectrum and a tendency towards a stronger bactericidal effect are in favour of monotherapy preceded by a short course of bitherapy, especially in cases of hospital-acquired infections.
抗生素治疗方案基于两种“最佳猜测”：致病微生物的种类及其耐药表型。对于免疫功能正常的重症感染患者，这种治疗方法是合理的。第三代头孢菌素，尤其是头孢他啶的微生物学和药代动力学特性，使其作为单一疗法或联合疗法的应用成为可能。抗菌谱极广且杀菌作用更强的趋势有利于在短期双药联合治疗后采用单一疗法，尤其是在医院获得性感染的情况下。
