长链非编码RNA：胃肠道癌细胞增殖的关键调节因子
Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation.
作者信息
Chen Jiaxin, Liu Shuiping, Hu Xiaotong
机构信息
Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
出版信息
Cell Death Discov. 2018 Apr 27;4:50. doi: 10.1038/s41420-018-0051-8. eCollection 2018.
Studies of long non-coding RNAs (lncRNAs) have been prevalent in the field of non-coding RNA regulation in recent years. LncRNAs exert crucial effects on malignant cell processes in the gastrointestinal system, including proliferation. Aberrant lncRNA expression, through both oncogenes and tumor suppressor genes, is instrumental to tumor cell proliferation. Here, we summarize the different molecular mechanisms and relevant signaling pathways through which multifarious lncRNAs regulate cell proliferation and we show that lncRNAs are potential biomarkers for gastrointestinal cancers.
近年来，长链非编码RNA（lncRNAs）的研究在非编码RNA调控领域十分普遍。lncRNAs对胃肠道系统中的恶性细胞进程，包括增殖，发挥着关键作用。通过癌基因和肿瘤抑制基因，lncRNA的异常表达有助于肿瘤细胞增殖。在此，我们总结了多种lncRNAs调控细胞增殖的不同分子机制及相关信号通路，并表明lncRNAs是胃肠道癌症的潜在生物标志物。
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