结直肠癌中的长链非编码RNA特征：研究进展与临床应用
Long non-coding RNA signature in colorectal cancer: research progression and clinical application.
作者信息
Wu Yudi, Xu Xiangshang
机构信息
GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, People's Republic of China.
出版信息
Cancer Cell Int. 2023 Feb 16;23(1):28. doi: 10.1186/s12935-023-02867-0.
Colorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are associated with aberrant expression of multiple coding and non-coding genes. Long non-coding RNAs (lncRNAs) have an important role in regulating gene stability as well as gene expression. Numerous current studies have shown that lncRNAs are promising biomarkers and therapeutic targets for colorectal cancer. In this review, we have searched the available literature to list lncRNAs involved in the pathogenesis and regulation of colorectal cancer. We focus on the role of lncRNAs in cancer promotion or suppression, their value in tumor diagnosis, and their role in treatment response and prognosis prediction. In addition, we will discuss the signaling pathways that these lncRNAs are mainly associated with in colorectal cancer. We also summarize the role of lncRNAs in colorectal precancerous lesions and colorectal cancer consensus molecular subgroups. We hope this review article will bring you the latest research progress and outlook on lncRNAs in colorectal cancer.
结直肠癌是排名靠前的人类恶性肿瘤之一。结直肠癌的发生和发展与多个编码基因和非编码基因的异常表达有关。长链非编码RNA（lncRNAs）在调节基因稳定性以及基因表达方面发挥着重要作用。目前大量研究表明，lncRNAs有望成为结直肠癌的生物标志物和治疗靶点。在本综述中，我们检索了现有文献，列出了参与结直肠癌发病机制和调控的lncRNAs。我们重点关注lncRNAs在癌症促进或抑制中的作用、它们在肿瘤诊断中的价值以及它们在治疗反应和预后预测中的作用。此外，我们将讨论这些lncRNAs在结直肠癌中主要相关的信号通路。我们还总结了lncRNAs在结直肠癌前病变和结直肠癌共识分子亚组中的作用。我们希望这篇综述文章能为您带来关于lncRNAs在结直肠癌方面的最新研究进展和展望。
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