Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Sci Rep. 2018 May 8;8(1):7301. doi: 10.1038/s41598-018-25639-7.
Glioblastoma (GBM) is the leading cause of high fatality cancer arising within the adult brain. Electrotherapeutic approaches offer new promise for GBM treatment by exploiting innate vulnerabilities of cancer cells to low intensity electric fields. This report describes the preclinical outcomes of a novel electrotherapeutic strategy called Intratumoral Modulation Therapy (IMT) that uses an implanted stimulation system to deliver sustained, titratable, low intensity electric fields directly across GBM-affected brain regions. This pilot technology was applied to in vitro and animal models demonstrating significant and marked reduction in tumor cell viability and a cumulative impact of concurrent IMT and chemotherapy in GBM. No off target neurological effects were observed in treated subjects. Computational modeling predicted IMT field optimization as a means to further bolster treatment efficacy. This sentinel study provides new support for defining the potential of IMT strategies as part of a more effective multimodality treatment platform for GBM.
胶质母细胞瘤（GBM）是成人脑内高致死性癌症的主要原因。电疗方法通过利用癌细胞对低强度电场的固有脆弱性，为 GBM 治疗带来了新的希望。本报告描述了一种名为肿瘤内调制治疗（IMT）的新型电疗策略的临床前结果，该策略使用植入式刺激系统在受 GBM 影响的脑区直接施加持续、可滴定的低强度电场。该先导技术已应用于体外和动物模型，证明了肿瘤细胞活力显著降低，并且 IMT 和化疗的联合应用具有累积效应。在治疗对象中未观察到非靶向神经学效应。计算模型预测 IMT 场优化是进一步增强治疗效果的一种手段。这项初步研究为确定 IMT 策略的潜力提供了新的支持，作为更有效的 GBM 多模态治疗平台的一部分。
