Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Women and Newborn Research, Intermountain Medical Center, Murray, UT, USA.
J Perinatol. 2018 Oct;38(10):1379-1385. doi: 10.1038/s41372-018-0108-9. Epub 2018 May 8.
Calprotectin is an antimicrobial protein found in stool when released by granulocytes. We sought to create stool calprotectin reference ranges in preterm neonates and to evaluate whether levels exceeding the upper reference interval are diagnostic for necrotizing enterocolitis (NEC).
Stool calprotectin was measured in premature neonates without gastrointestinal pathology to create reference intervals. For comparison, levels from infants undergoing "rule out NEC" evaluations were plotted on these reference intervals.
Stool calprotectin reference intervals were created according to gestational age at birth and corrected gestational age. Levels during "rule out NEC" evaluations were more often above the upper reference interval with NEC vs. those without NEC.
Stools from preterm neonates have a higher range of calprotectin than stools from healthy term neonates. In evaluating preterm neonates for NEC with stool calprotectin, a calprotectin upper reference interval that incorporates corrected gestational age best predicts the diagnosis of NEC.
钙卫蛋白是一种存在于粪便中的抗菌蛋白，当粒细胞释放时就会出现。我们旨在为早产儿创建粪便钙卫蛋白参考范围，并评估其是否超过上参考区间可用于诊断坏死性小肠结肠炎（NEC）。
在没有胃肠道病理的早产儿粪便中测量钙卫蛋白以创建参考范围。为了进行比较，将接受“排除 NEC”评估的婴儿的水平绘制在这些参考范围内。
根据出生时的胎龄和校正胎龄创建了粪便钙卫蛋白参考范围。在“排除 NEC”评估期间，NEC 组的水平比无 NEC 组更常高于上参考区间。
早产儿的粪便钙卫蛋白范围高于健康足月新生儿的粪便钙卫蛋白范围。在使用粪便钙卫蛋白评估早产儿 NEC 时，包含校正胎龄的钙卫蛋白上参考区间最能预测 NEC 的诊断。
