Sun Bolin, Lv Yongbin, Xing Dong, Li Jianlin
Interventional Therapy Ward, Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Department of Radiology, Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Oncol Lett. 2018 May;15(5):7669-7674. doi: 10.3892/ol.2018.8281. Epub 2018 Mar 15.
The imaging performance and clinical value of contrast-enhanced ultrasonography (CEUS) combined with CT in diagnosis of liver cancer were investigated. A total of 426 liver cancer patients treated in Yuhuangding Hospital (Yantai, China) from February 2011 to May 2016 were selected. Among them, 222 patients underwent CEUS examination, 204 patients underwent CT examination, and 102 patients underwent CEUS combined with CT examination. Sensitivity and specificity of the three methods were examined. CT showed a low density in 92.6% of patients (189 patients) and a high-low hybrid density in 6.4% (13 patients), with calcification seen in 2.5% of patients (5 patients) and bleeding in 3.4% (7 patients). Lesions: 76.5% (156 cases) of patients with multiple type, 23.5% (48 cases) with single type. CEUS showed overall enhancement in 53.2% patients (118 cases), heterogenous enhancement in 16.7% (37 cases), peripheral enhancement in 18.9% of patients (42 cases), necrosis of liquefaction in 11.3% (25 cases). In 65.3% (145 cases) of patients, the portal venous phase and the delayed phase showed a low enhancement, while 34.7% (77 cases) showed no enhancement. The sensitivity and specificity rates of CEUS combined with CT detection of liver cancer were 87.8, 88.2 and 94.1%, respectively. The ROC curve analysis showed that the sensitivity and specificity of CEUS in the diagnosis of liver cancer were 76.8 and 78.9%, respectively. The sensitivity and specificity of CT were 81.2 and 85.5%, respectively. The sensitivity and specificity of CEUS combined with CT were 90.4 and 92.7%, respectively. CEUS combined with CT detection can make-up for the deficiencies of each other and effectively improve the coincidence rate of liver cancer diagnosis, which can be used as an effective examination method for the diagnosis of liver cancer.
探讨超声造影（CEUS）联合CT在肝癌诊断中的成像性能及临床价值。选取2011年2月至2016年5月在烟台毓璜顶医院治疗的426例肝癌患者。其中，222例行CEUS检查，204例行CT检查，102例行CEUS联合CT检查。检测三种方法的灵敏度和特异度。CT检查显示92.6%（189例）患者为低密度影，6.4%（13例）为高低混合密度影，2.5%（5例）患者有钙化，3.4%（7例）有出血。病灶类型：76.5%（156例）患者为多发型，23.5%（48例）为单发型。CEUS检查显示53.2%（118例）患者为整体增强，16.7%（37例）为不均匀增强，18.9%（42例）为周边增强，11.3%（25例）为液化坏死。65.3%（145例）患者门静脉期及延迟期呈低增强，34.7%（77例）无增强。CEUS联合CT检测肝癌的灵敏度和特异度分别为87.8%、88.2%和94.1%。ROC曲线分析显示，CEUS诊断肝癌的灵敏度和特异度分别为76.8%和78.9%。CT的灵敏度和特异度分别为81.2%和85.5%。CEUS联合CT的灵敏度和特异度分别为90.4%和92.7%。CEUS联合CT检测可相互弥补不足，有效提高肝癌诊断符合率，可作为肝癌诊断的有效检查方法。
