Department of Pharmacognosy, School of Pharmacy, Fudan University , Shanghai 201203, People's Republic of China.
J Nat Prod. 2014 Jan 24;77(1):42-8. doi: 10.1021/np400571x. Epub 2013 Dec 30.
Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa. The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP50 values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade.
从牡丹根皮中分离得到了 6 个新的（1-6）和 19 个已知的单萜苷。单萜苷 1、2、7、10-19 和 22 具有抗补体作用，CH50 和 AP50 值分别在 0.14 至 2.67 mM 和 0.25 至 3.67 mM 范围内。在机制研究中，牡丹酚苷 A（1）与 C1q、C3、C5 和 C9 相互作用，而没食子酰芍药苷（12）和没食子酰氧化芍药苷（19）作用于补体激活级联中的 C1q、C3 和 C5 成分。
