Bioconjug Chem. 2018 Jun 20;29(6):1793-1808. doi: 10.1021/acs.bioconjchem.8b00026. Epub 2018 May 23.
Nanoparticles, the building blocks of nanotechnology, have been widely utilized in various biomedical applications, such as detection, diagnosis, imaging, and therapy. However, another emerging, albeit under-represented, area is the employment of nanoparticles as tools to understand cellular processes (e.g., oxidative stress-induced signaling cascades). Such investigations have enormous potential to characterize a disease from a different perspective and unravel some new features that otherwise would have remained a mystery. In this review, we summarize the intrinsic biological properties of unmodified as well surface modified nanoparticles and discuss how such properties could be utilized to interrogate biological processes and provide a perspective for future evolution of this field.
纳米粒子是纳米技术的基本组成部分，已广泛应用于各种生物医学领域，如检测、诊断、成像和治疗。然而，纳米粒子作为工具来理解细胞过程（例如，氧化应激诱导的信号级联）的应用，虽然还不太受关注，但也是一个新兴领域。这些研究从不同的角度对疾病进行特征描述，并揭示一些新的特征，否则这些特征仍将是一个谜。在这篇综述中，我们总结了未修饰和表面修饰的纳米粒子的固有生物学特性，并讨论了如何利用这些特性来探究生物过程，并为该领域的未来发展提供了一个视角。
