生物样本库在移植中的作用。
Role of biobanks in transplantation.
作者信息
Hanif Z, Sufiyan N, Patel M, Akhtar M Z
机构信息
Royal Berkshire Hospital, Reading, RG1, UK.
Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK.
出版信息
Ann Med Surg (Lond). 2018 Mar 1;28:30-33. doi: 10.1016/j.amsu.2018.02.007. eCollection 2018 Apr.
The establishment of bio-banks together with high throughput technologies, such as genomics, transcriptomics and proteomics has opened new frontiers in biomarker discovery and the development of systems biology approaches to identifying key pathways that could be exploited to improve outcomes of solid organ transplantation. One of the major challenges in organ donation has been the lack of access to large scale well characterised material to facilitate projects that aim to characterise injury to donor organs and identify biomarkers. This may have hampered research in the field of organ donation by not allowing researchers to materials of high quality and lower pre-analytical variability. We describe in this manuscript the need for bio-banks in organ donation, research opportunities and the particular challenges in establishing such an initiative.
生物样本库与高通量技术（如基因组学、转录组学和蛋白质组学）的建立，为生物标志物的发现以及系统生物学方法的发展开辟了新的前沿领域，这些方法用于识别可被利用以改善实体器官移植结果的关键途径。器官捐赠的主要挑战之一是缺乏大规模特征明确的材料，以推动旨在描述供体器官损伤和识别生物标志物的项目。这可能因无法让研究人员获得高质量且分析前变异性较低的材料而阻碍了器官捐赠领域的研究。我们在本手稿中描述了器官捐赠中生物样本库的必要性、研究机会以及建立此类项目的特殊挑战。
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