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钙黄长石用作碱性可生物降解植入物治疗骨质疏松性骨缺损。

Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect.

作者信息

Liu Wenlong, Wang Ting, Zhao Xiaoli, Dan Xiuli, Lu William W, Pan Haobo

机构信息

Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Department of Orthopaedics and Traumatology, Faculty of Medicine, The University of Hong Kong, Hong Kong.

出版信息

Bioact Mater. 2016 Dec 7;1(2):151-159. doi: 10.1016/j.bioactmat.2016.11.004. eCollection 2016 Dec.

Abstract

In osteoporosis scenario, tissue response to implants is greatly impaired by the deteriorated bone regeneration microenvironment. In the present study, a Mg-containing akermanite (Ak) ceramic was employed for the treatment of osteoporotic bone defect, based on the hypothesis that both beneficial ions ( Mg) released by the implants and the weak alkaline microenvironment pH (μe-pH) it created may play distinct roles in recovering the abnormal bone regeneration by stimulating osteoblastic anabolic effects. The performance of Ak, β-tricalcium phosphate (β-TCP) and Hardystone (Har) in healing a 3 mm bone defect on the ovariectomized (OVX) osteoporotic rat model was evaluated. Our results indicated that, there's more new bone formed in Ak group than in β-TCP or Har group at week 9. The initial μe-pHs of Ak were significantly higher than that of the β-TCP and Blank group, and this weak alkaline condition was maintained till at least 9 weeks post-surgery. Increased osteoblastic activity which was indicated by higher osteoid secretion was observed in Ak group at week 4 to week 9. An intermediate layer which was rich in phosphorus minerals and bound directly to the new forming bone was developed on the surface of Ak. In a summary, our study demonstrates that Ak exhibits a superior bone regenerative performance under osteoporosis condition, and might be a promising candidate for the treatment of osteoporotic bone defect and fracture.

摘要

在骨质疏松的情况下,植入物的组织反应会因骨再生微环境的恶化而受到极大损害。在本研究中,基于植入物释放的有益离子(镁)及其产生的弱碱性微环境pH值(μe-pH)可能通过刺激成骨细胞合成代谢作用在恢复异常骨再生中发挥不同作用的假设,采用含镁的硅钙石(Ak)陶瓷来治疗骨质疏松性骨缺损。评估了Ak、β-磷酸三钙(β-TCP)和硬石(Har)在去卵巢(OVX)骨质疏松大鼠模型上修复3毫米骨缺损的性能。我们的结果表明,在第9周时,Ak组形成的新骨比β-TCP组或Har组更多。Ak的初始μe-pH值显著高于β-TCP组和空白组,并且这种弱碱性状态至少维持到术后9周。在第4周和第9周时,Ak组观察到成骨细胞活性增加,表现为类骨质分泌增加。Ak表面形成了一层富含磷矿物质且直接与新形成骨结合的中间层。总之,我们的研究表明,Ak在骨质疏松条件下表现出优异的骨再生性能,可能是治疗骨质疏松性骨缺损和骨折的有前途候选材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beb5/5883956/7671b3ba265a/fx1.jpg

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