Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Sleep. 2018 Jul 1;41(7). doi: 10.1093/sleep/zsy086.
The fruit fly Drosophila melanogaster, like most organisms, exhibits increased sleep amount and depth in young compared to mature animals. While the fly has emerged as a powerful model for studying sleep during development, qualitative behavioral features of sleep ontogeny and its genetic control are poorly understood. Here we find that, in addition to increased sleep time and intensity, young flies sleep with less place preference than mature adults, and, like mammals, exhibit more motor twitches during sleep. In addition, we show that ontogenetic changes in sleep amount, twitch, and place preference are preserved across sleep mutants with lesions in distinct molecular pathways. Our results demonstrate that sleep ontogeny is characterized by multifaceted behavioral changes, including quantitative and qualitative alterations to sleep as animals mature. Further, the preservation of sleep ontogenetic changes despite mutations that alter sleep time suggests independent genetic control mechanisms for sleep maturation.
黑腹果蝇与大多数生物一样，在幼年时比成年时表现出更多的睡眠量和更深的睡眠。虽然苍蝇已经成为研究发育过程中睡眠的强大模型，但睡眠发生的定性行为特征及其遗传控制知之甚少。在这里，我们发现，除了睡眠时间和强度增加外，幼年苍蝇的睡眠偏好比成熟成虫少，并且像哺乳动物一样，在睡眠期间表现出更多的运动抽搐。此外，我们还表明，尽管在不同的分子途径中出现了病变，但睡眠量、抽搐和睡眠偏好的发育变化在睡眠突变体中仍然保持不变。我们的研究结果表明，睡眠发生的特征是多方面的行为变化，包括随着动物成熟，睡眠的定量和定性改变。此外，尽管改变睡眠时间的突变会导致睡眠发生变化，但睡眠发生的变化仍能得到保存，这表明睡眠成熟的遗传控制机制是独立的。
