Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Medical School of Yangtze University, Jingzhou 434023, China.
Acta Biochim Biophys Sin (Shanghai). 2018 Jun 1;50(6):605-614. doi: 10.1093/abbs/gmy049.
MicroRNAs (miRNAs), some small non-coding RNAs that regulate gene expression at the posttranscriptional level, are always aberrantly expressed in carcinomas. In this study, we found that miR-23b-3p was remarkably up-regulated in human esophageal squamous cell carcinoma cells and tissues. Moreover, miR-23b-3p could induce the proliferation, invasion, and metastasis in vitro. EBF3 was identified as the direct downstream target gene of miR-23b-3p and ectogenic EBF3 could strongly inhibit the proliferation, invasion, and metastasis in vitro. Furthermore, it was found that miR-23b-3p could regulate epithelial-to-mesenchymal transition progress by blocking EBF3. Therefore, it was concluded that miR-23b-3p targeted EBF3 to accelerate the proliferation, invasion, and metastasis in ESCC.
微小 RNA（miRNA）是一类在转录后水平调控基因表达的非编码小分子 RNA，在癌组织中常呈现异常表达。本研究发现 miR-23b-3p 在人食管鳞状细胞癌细胞和组织中显著上调。此外，miR-23b-3p 可诱导体外细胞的增殖、侵袭和转移。EBF3 被鉴定为 miR-23b-3p 的直接下游靶基因，外源性 EBF3 可强烈抑制体外细胞的增殖、侵袭和转移。此外，研究发现 miR-23b-3p 可以通过阻断 EBF3 来调节上皮间质转化过程。因此，我们得出结论，miR-23b-3p 通过靶向 EBF3 促进 ESCC 的增殖、侵袭和转移。
