Digestive System Department, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Jiangxi Provincial Branch of China Clinical Medical Research Center for Geriatric Diseases, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Cell Death Dis. 2023 Jan 6;14(1):9. doi: 10.1038/s41419-022-05541-x.
Esophageal squamous cell carcinoma (ESCC) is characterized by high morbidity and mortality. Circular RNAs (circRNAs) play an important role in tumor progression. We discovered an aberrantly expressed circRNA (hsa_circ_0021727) in patients with ESCC. However, the mechanism of action of hsa_circ_0021727 in tumors is unclear. The present study aimed to investigate the biological role of hsa_circ_0021727 and its mechanism in ESCC progression. We screened for the expression of hsa_circ_0021727 in ESCC patients. Patients with ESCC with high expression of hsa_circ_0021727 had shorter survival than those with low expression. Hsa_circ_0021727 promoted the proliferation, invasion, and migration of ESCC cells. However, miR-23b-5p inhibited this ability of hsa_circ_0021727. MiR-23b-5p acts by targeting TAK1-binding protein 1 (TAB1). Upregulation of TAB1 can activate the nuclear factor kappa B (NFκB) pathway. Hsa_circ_0021727 promoted ESCC progression by activating TAB1/NFκB pathway by sponging miR-23b-5p. In addition, in vivo experiments also confirmed that hsa_circ_0021727 could promote the proliferation, invasion, and migration of ESCC cells. In short, hsa_circ_0021727 promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway. These findings might provide potential targets to treat ESCC.
食管鳞状细胞癌（ESCC）的发病率和死亡率均较高。环状 RNA（circRNA）在肿瘤进展中发挥着重要作用。我们在 ESCC 患者中发现了一种异常表达的 circRNA（hsa_circ_0021727）。然而，hsa_circ_0021727 在肿瘤中的作用机制尚不清楚。本研究旨在探讨 hsa_circ_0021727 在 ESCC 进展中的生物学作用及其机制。我们筛选了 ESCC 患者中 hsa_circ_0021727 的表达情况。hsa_circ_0021727 高表达的 ESCC 患者的生存率低于低表达的患者。hsa_circ_0021727 促进了 ESCC 细胞的增殖、侵袭和迁移。然而，miR-23b-5p 抑制了 hsa_circ_0021727 的这种能力。miR-23b-5p 通过靶向 TAK1 结合蛋白 1（TAB1）发挥作用。TAB1 的上调可以激活核因子 kappa B（NFκB）通路。hsa_circ_0021727 通过海绵吸附 miR-23b-5p 来激活 TAB1/NFκB 通路，从而促进 ESCC 的进展。此外，体内实验也证实 hsa_circ_0021727 可促进 ESCC 细胞的增殖、侵袭和迁移。总之，hsa_circ_0021727 通过靶向 miR-23b-5p 激活 TAB1/NFκB 通路促进 ESCC 的进展。这些发现可能为治疗 ESCC 提供潜在的靶点。
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