肺癌的光谱 CT 成像：光谱参数的定量分析及其与肿瘤特征的相关性。

Spectral CT Imaging of Lung Cancer: Quantitative Analysis of Spectral Parameters and Their Correlation with Tumor Characteristics.

机构信息

Radiology Department, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136 Jingzhou Street, Xiangyang 441021, HubeiChina.

出版信息

Acad Radiol. 2018 Nov;25(11):1398-1404. doi: 10.1016/j.acra.2018.04.017. Epub 2018 May 8.

DOI:10.1016/j.acra.2018.04.017

PMID:29752156

Abstract

RATIONALE AND OBJECTIVES

Spectral computed tomography (CT) imaging is widely used in the diagnosis of various cancers. This study aimed to analyze the characteristics of lung squamous cell carcinoma (SC) and adenocarcinoma (AC) using spectral CT imaging.

METHODS

Sixty patients who were examined via spectral CT imaging and confirmed as having AC or SC via surgery and pathology were enrolled in this research project. A spectrum CT scanner was used, and both plain and enhanced CT scans were conducted to acquire spectral images. All patients' samples were used to detect the expression of thyroid transcription factor-1 (TTF-1) and epidermal growth factor receptor (EGFR) in cancer cells via immunohistochemical methods.

RESULTS

Among the 27 cases with AC, 18 cases were identified as TTF-1 positive, 9 cases were found to be TTF-1 negative, 20 cases were confirmed as EGFR positive, and 7 cases were found to be EGFR negative. Among the 33 patients with SC, 6 cases were identified as TTF-1 positive, 27 cases were found to be TTF-1 negative, 19 cases were confirmed as EGFR positive, and 14 cases were found to be EGFR negative. No statistically significant differences were observed in normalized iodine concentration (NIC), K values, and calcium content between the TTF-1-positive and TTF-1-negative groups when considering patients. Statistically significant differences in NIC and K values were noted between the EGFR-positive and EGFR-negative groups among patients with AC, but no such difference was observed regarding calcium content. Significant differences in NIC, K values, and calcium content were observed between the EGFR-positive and EGFR-negative groups among patients with SC.

CONCLUSIONS

In lung cancer cells, the parameters of spectral CT imaging, including NIC and K values, reflect the microvessel density and blood supply. Calcium content is an indicator of the growth status of lung SC.

摘要

目的和背景

光谱 CT 成像在各种癌症的诊断中得到了广泛的应用。本研究旨在利用光谱 CT 成像分析肺鳞癌（SC）和腺癌（AC）的特征。

方法

本研究纳入了 60 名经光谱 CT 成像检查并通过手术和病理检查确诊为 AC 或 SC 的患者。使用光谱 CT 扫描仪进行平扫和增强 CT 扫描以获取光谱图像。所有患者的样本均通过免疫组织化学方法检测癌细胞中甲状腺转录因子-1（TTF-1）和表皮生长因子受体（EGFR）的表达。

结果

在 27 例 AC 中，18 例 TTF-1 阳性，9 例 TTF-1 阴性，20 例 EGFR 阳性，7 例 EGFR 阴性。在 33 例 SC 患者中，6 例 TTF-1 阳性，27 例 TTF-1 阴性，19 例 EGFR 阳性，14 例 EGFR 阴性。考虑到患者，TTF-1 阳性和 TTF-1 阴性组之间的标准化碘浓度（NIC）、K 值和钙含量无统计学差异。在 AC 患者中，EGFR 阳性和 EGFR 阴性组之间的 NIC 和 K 值存在统计学差异，但钙含量无差异。在 SC 患者中，EGFR 阳性和 EGFR 阴性组之间的 NIC、K 值和钙含量存在显著差异。