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非衰老细胞能够耐受核纤层的严重紊乱。

Non-senescent tolerates severe disturbances in the nuclear lamina.

作者信息

Klimovich Alexander, Rehm Arvid, Wittlieb Jörg, Herbst Eva-Maria, Benavente Ricardo, Bosch Thomas C G

机构信息

Zoological Institute, Christian-Albrechts University of Kiel, Kiel D-24118, Germany.

Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg D-97074, Germany.

出版信息

Aging (Albany NY). 2018 May 10;10(5):951-972. doi: 10.18632/aging.101440.

DOI:10.18632/aging.101440
PMID:29754147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5990382/
Abstract

The cnidarian is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of . We demonstrate that proliferation of stem cells in is robust against the disturbance of Lamin expression and localization. While Lamin is indispensable for , the stem cells tolerate overexpression, downregulation and mislocalization of Lamin, and disturbances in the nuclear envelope structure. This extraordinary robustness may underlie the indefinite self-renewal capacity of stem cells and the non-senescence of . A relatively low complexity of the nuclear envelope architecture in basal Metazoa might allow for their extreme lifespans, while an increasing complexity of the nuclear architecture in bilaterians resulted in restricted lifespans.

摘要

刺胞动物以其无限寿命和无衰老现象而闻名，这归因于其干细胞的无限自我更新能力。虽然核纤层蛋白家族的蛋白质被认为是影响人类和小鼠衰老及寿命的关键因素，但其在长寿动物的极端长寿和无衰老现象中的假定作用仍不清楚。在此，我们分析了单个核纤层蛋白在[具体动物名称未给出]无衰老现象中的作用。我们证明，[具体动物名称未给出]干细胞的增殖对核纤层蛋白表达和定位的干扰具有很强的抗性。虽然核纤层蛋白对于[具体动物名称未给出]是不可或缺的，但干细胞能够耐受核纤层蛋白的过表达、下调和错误定位，以及核膜结构的干扰。这种非凡的抗性可能是干细胞无限自我更新能力和[具体动物名称未给出]无衰老现象的基础。基础后生动物核膜结构相对较低的复杂性可能使其具有极长的寿命，而两侧对称动物核结构复杂性的增加导致寿命受限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/6452ae8f351e/aging-10-101440-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/524e367df786/aging-10-101440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/0af125b1d0ff/aging-10-101440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/73bb45f71699/aging-10-101440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/bff1e798b63f/aging-10-101440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/66cd048e80ad/aging-10-101440-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/6707a8e76c9c/aging-10-101440-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/1e6eccc6b209/aging-10-101440-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/c2e36ea458fa/aging-10-101440-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/deab83bd89fb/aging-10-101440-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/f964d16c4ece/aging-10-101440-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/6452ae8f351e/aging-10-101440-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/524e367df786/aging-10-101440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/0af125b1d0ff/aging-10-101440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/73bb45f71699/aging-10-101440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/bff1e798b63f/aging-10-101440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/66cd048e80ad/aging-10-101440-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/6707a8e76c9c/aging-10-101440-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/1e6eccc6b209/aging-10-101440-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/c2e36ea458fa/aging-10-101440-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/deab83bd89fb/aging-10-101440-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/f964d16c4ece/aging-10-101440-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0396/5990382/6452ae8f351e/aging-10-101440-g011.jpg

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