Genetic variants of -rs671 and -rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population.

OBJECTIVE

Acetaldehyde dehydrogenase 2 () and cytochrome P450 2E1 () have been associated with hepatocellular carcinoma (HCC) susceptibility and prognosis. The polymorphisms rs671 and rs2031920 are reportedly correlated with the prevalence of HCC in other countries. The aim of this study was to investigate associations between and , and HCC susceptibility in a population of Guangxi, southern China, an area with a high incidence of HCC.

PATIENTS AND METHODS

The study cohort included 300 HCC cases, 292 healthy controls for HCC susceptibility analysis, and another 20 HCC cases and 10 healthy controls for ascertainment. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method.

RESULTS

The study results demonstrated that mutant genotypes of (G/A and A/A) led to significant differences in HCC susceptibility, as compared with the wild genotype (G/G) with the same C1/C1 genotype in non-drinking individuals (adjusted =0.010, OR=0.20, 95% CI=0.06-0.68). The mutant genotypes of (C1/C2 and C2/C2) brought about significant differences in HCC susceptibility, as compared with the wild genotype (C1/C1) and the same G/G genotype (adjusted =0.025, OR=0.42, 95% CI=0.20-0.90). Drinking plays a role in HCC susceptibility in the same G/G genotype individuals (adjusted =0.004, OR=0.32, 95% CI=0.15-0.69), but had no impact when combined with for analysis (all >0.05).

CONCLUSION

These results suggest that the mutant genotypes of and may be protective factors for HCC susceptibility in Guangxi province, China.