SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134, Florence, Italy.
Centro di Riferimento per la Regione Toscana per le Malattie Infettive in Gravidanza, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Infection. 2018 Oct;46(5):693-699. doi: 10.1007/s15010-018-1150-4. Epub 2018 May 15.
Data from 215 pregnant women exposed to varicella and 276 with varicella observed at the Tuscany Reference Center for Infectious Diseases in Pregnancy, Florence, Italy, in the period 1997-2016 were retrospectively collected. The risk of developing varicella was lower in exposed women who received varicella zoster immunoglobulin compared with those who did not receive it [42% (21 of 50) vs 72% (13 of 18); p = 0.0263]. Typical congenital varicella syndrome was observed in 1.56% of fetuses/neonates born from pregnant women with varicella.
回顾性收集了来自意大利佛罗伦萨托斯卡纳传染病参考中心在 1997 年至 2016 年期间观察到的 215 名暴露于水痘的孕妇和 276 名患有水痘的孕妇的数据。与未接受水痘带状疱疹免疫球蛋白的孕妇相比，接受该免疫球蛋白的暴露孕妇发生水痘的风险较低[42%（21/50）比 72%（18/25）；p=0.0263]。在水痘孕妇所生的胎儿/新生儿中，有 1.56%出现典型的先天性水痘综合征。
