利用微生物作为药物：微生物生态系统疗法。
Using bugs as drugs: Microbial ecosystem therapeutics.
作者信息
Allen-Vercoe E, Petrof E O
机构信息
Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON.
Department of Medicine, Queen's University, Kingston, ON.
出版信息
Can Commun Dis Rep. 2015 Nov 19;45(Suppl 5):3-6. doi: 10.14745/ccdr.v41is5a01.
The human gut harbours a dense and highly diverse microbial ecosystem-the microbiota-that plays an important role in the maintenance of health. Modern lifestyle practices, including widespread antibiotic use, have degraded microbiota diversity, compromising the integrity of this vital ecosystem and creating susceptibility to diseases such as infection. Treatment of patients to restore the diversity of the gut microbiota offers a logical solution to disease. Although fecal microbial therapy (FMT) has started to gain traction as an effective method to effect this restoration, it is not without risks and there are significant barriers to its implementation in the clinic. Some of the risks and challenges with FMT are addressed by microbial ecosystem therapeutics (MET), an alternative approach to FMT that uses selected, defined microbial ecosystems to redress microbiota balance and functionality. The time has come for the use of bugs as drugs.
人类肠道中栖息着一个密集且高度多样的微生物生态系统——微生物群，它在维持健康方面发挥着重要作用。包括广泛使用抗生素在内的现代生活方式，已经降低了微生物群的多样性，损害了这个重要生态系统的完整性，并使人易患感染等疾病。治疗患者以恢复肠道微生物群的多样性为疾病提供了一个合理的解决方案。尽管粪便微生物疗法（FMT）作为实现这种恢复的有效方法已开始受到关注，但它并非没有风险，而且在临床实施中存在重大障碍。微生物生态系统疗法（MET）解决了FMT的一些风险和挑战，MET是FMT的一种替代方法，它使用选定的、明确的微生物生态系统来纠正微生物群的平衡和功能。用微生物作为药物的时代已经到来。
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