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特应性皮炎患者对室外和室内真菌的致敏情况,以及与花生和核桃食物过敏发生的关系。

Sensitisation to outdoor and indoor fungi in atopic dermatitis patients and the relation to the occurrence of food allergy to peanuts and walnuts.

机构信息

Department of Dermatology and Venereology, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Department of Medical Biophysics, Medical Faculty of Charles University, Hradec Králové, Czech Republic.

出版信息

Mycoses. 2018 Sep;61(9):698-703. doi: 10.1111/myc.12795. Epub 2018 May 31.

Abstract

The aim of this study is the evaluation of the relation between the sensitisation to outdoor and indoor fungi and allergy to peanuts and walnuts in atopic dermatitis patients aged 14 years and older. The complete dermatological and allergological examinations were performed in all included patients; the occurrence of food allergy to peanuts and walnuts was recorded (specific IgE, skin prick test, history of allergic reaction) and the sensitisation to mixture of outdoor fungi and indoor fungi was also examined (skin prick test, specific IgE). The statistical evaluation of the relation between the sensitisation to outdoor and indoor fungi and the occurrence of food allergy to peanuts and walnuts was performed; 329 patients were included in the study, 110 men and 219 women, the average age 26.8 years. The sensitisation to outdoor fungi was recorded in 91 patients (28%), the sensitisation to indoor fungi was recorded in 61 patients (18.5%), the occurrence of food allergy to peanuts was confirmed in 90 (27%) patients and to walnuts in 121 (36.7%) patients. We confirmed, that patients suffering from sensitisation to outdoor fungi suffer significantly more from food allergy to peanuts and walnuts. The significant relation between the sensitisation to indoor fungi and food allergy to peanuts and walnuts was not confirmed.

摘要

本研究旨在评估 14 岁及以上特应性皮炎患者对外源性和内源性真菌致敏与花生和核桃过敏之间的关系。所有纳入的患者均进行了完整的皮肤科和过敏检查;记录了食物过敏(花生和核桃)的发生情况(特异性 IgE、皮肤点刺试验、过敏反应史),并检查了对室外混合真菌和室内真菌的致敏情况(皮肤点刺试验、特异性 IgE)。对室外和室内真菌致敏与花生和核桃食物过敏发生之间的关系进行了统计学评估;研究纳入了 329 例患者,其中男性 110 例,女性 219 例,平均年龄 26.8 岁。91 例(28%)患者对外源性真菌过敏,61 例(18.5%)患者对内源性真菌过敏,90 例(27%)患者确认对花生过敏,121 例(36.7%)患者对核桃过敏。我们证实,对外源性真菌过敏的患者更易患花生和核桃过敏。然而,内源性真菌致敏与花生和核桃过敏之间的关系并不显著。

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