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14岁及以上特应性皮炎患者对花生的过敏反应及其与食物过敏、吸入性过敏原、支气管哮喘和鼻炎的关联

Allergy to Peanuts in Atopic Dermatitis Patients 14 Year or Older and the Association with Food Hypersensitivity, Inhalant Allergens, Asthma Bronchiale and Rhinitis.

作者信息

Čelakovská Jarmila, Bukač Josef, Ettler Karel, Vaneckova Jaroslava, Ettlerova Kvetuse

机构信息

Department of Dermatology and Venereology, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Department of Medical Biophysics, Medical Faculty of Charles University, Hradec Králové, Czech Republic.

出版信息

Indian J Dermatol. 2018 Jul-Aug;63(4):317-322. doi: 10.4103/ijd.IJD_576_17.

Abstract

BACKGROUND

In adult patients suffering from atopic dermatitis (AD), studies investigating the co-prevalence of AD and food allergy are still scarce, and exact data are not available.

AIMS AND OBJECTIVES

To evaluate the occurrence of food allergy to peanuts in significant relation to food hypersensitivity, inhalant allergy and to asthma bronchial and rhinitis.

MATERIALS AND METHODS

Altogether 332 patients of AD 14 year or older were included in the study. The complete dermatological and allergological examinations were performed in all included patients (including examination of specific immunoglobulin E, skin prick test to different food and inhalant allergens, anamnestic data about food reactions, evaluation of allergic rhinitis, and allergic asthma bronchiale). We evaluated whether there was some relation between the food allergy to peanuts and followed parameters. Pairs of these categories were entered in the contingency tables, and the Chi-square test for the relationship of these variables was performed with the level of significance set to 5%.

RESULTS

Altogether 332 persons suffering from AD were included in the study of which 120 were male and 212 were female; the average age was 27.2 year. The significant relation between the allergy to peanuts and the occurrence of food hypersensitivity (FH) reactions to tomatoes, kiwi, apples, oranges, carrot and to the sensitization to grass, trees, mites, and the occurrence of rhinitis was found.

CONCLUSION

The significant relation between the allergy to peanuts and the occurrence of FH reactions and the sensitization to inhalant allergens and rhinitis was found. The future studies may show if the decrease in food allergy to peanuts can lead to the decrease of the occurrence of other FH reactions and sensitization to inhalant allergens and rhinitis in AD patients.

摘要

背景

在成年特应性皮炎(AD)患者中,关于AD与食物过敏共患病率的研究仍然很少,尚无确切数据。

目的

评估花生食物过敏与食物超敏反应、吸入性过敏、支气管哮喘和鼻炎之间的显著关系。

材料与方法

本研究共纳入332例14岁及以上的AD患者。对所有纳入患者进行了全面的皮肤科和过敏科检查(包括特异性免疫球蛋白E检测、针对不同食物和吸入性过敏原的皮肤点刺试验、食物反应的既往史数据、过敏性鼻炎评估以及过敏性支气管哮喘评估)。我们评估了花生食物过敏与以下参数之间是否存在某种关系。将这些类别对录入列联表,并对这些变量之间的关系进行卡方检验,显著性水平设定为5%。

结果

本研究共纳入332例AD患者,其中男性120例,女性212例;平均年龄为27.2岁。发现花生过敏与对西红柿、猕猴桃、苹果、橙子、胡萝卜的食物超敏反应(FH)以及对草、树、螨虫的致敏反应和鼻炎的发生之间存在显著关系。

结论

发现花生过敏与FH反应的发生以及对吸入性过敏原和鼻炎的致敏反应之间存在显著关系。未来的研究可能会表明,花生食物过敏的减少是否会导致AD患者中其他FH反应的发生率以及对吸入性过敏原和鼻炎的致敏反应降低。

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