Li Song-Wei, Chen Wen-Ting, Yao Li-Gong, Guo Yue-Wei
School of Pharmacy, Nanchang University, Nanchang 330006, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
Steroids. 2018 Aug;136:17-21. doi: 10.1016/j.steroids.2018.05.009. Epub 2018 May 18.
Two new steroids, ximaosteroid E (1) and ximaosteroid F (2), along with two known related compounds (3 and 4), were isolated from the Chinese soft coral Sinularia sp. Notably, 1 possesses an uncommon dihydrofuran group. Their structures were established from extensive spectroscopic analyses and comparisons of their spectral data with those reported in the literature. The absolute configuration of 2 was determined by applying the modified Mosher's method. In bioassay, compounds 1, 2, and 4 showed significant cytotoxicity against the HL-60 tumor cell line with IC values of 1.79, 4.03 and 0.69 μM, respectively.
从中国软珊瑚中华角珊瑚（Sinularia sp.）中分离出两种新的甾体化合物，西马甾体E（1）和西马甾体F（2），以及两种已知的相关化合物（3和4）。值得注意的是，1具有一个不常见的二氢呋喃基团。通过广泛的光谱分析以及将它们的光谱数据与文献报道的数据进行比较，确定了它们的结构。通过应用改良的莫舍尔方法确定了2的绝对构型。在生物测定中，化合物1、2和4对HL-60肿瘤细胞系显示出显著的细胞毒性，IC值分别为1.79、4.03和0.69 μM。
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