Chang William G, Niklason Laura E
Yale University, New Haven, CT, USA.
NPJ Regen Med. 2017;2. doi: 10.1038/s41536-017-0011-6. Epub 2017 Mar 27.
Vascular tissue engineering has significant potential to make a major impact on a wide array of clinical problems. Continued progress in understanding basic vascular biology will be invaluable in making further advancements. Past and current achievements in tissue engineering of microvasculature to perfuse organ specific constructs, small vessels for dialysis grafts, and modified synthetic and pediatric large caliber-vessel grafts will be discussed. An emphasis will be placed on clinical trial results with small and large-caliber vessel grafts. Challenges to achieving engineered constructs that satisfy the physiologic, immunologic, and manufacturing demands of engineered vasculature will be explored.
血管组织工程在解决一系列临床问题方面具有巨大潜力。深入了解基础血管生物学的持续进展对于取得进一步的进步将非常宝贵。本文将讨论过去和当前在组织工程领域取得的成果，包括构建灌注特定器官的微血管、用于透析移植的小血管以及改良的合成和儿科大口径血管移植物。重点将放在小口径和大口径血管移植物的临床试验结果上。我们还将探讨在实现满足工程化血管生理、免疫和制造要求的工程构建物方面所面临的挑战。
