Sun Xiujuan, Malhotra Anshoo
Pathology Department, Liuzhou Municipal Liutie Central Hospital, Liuzhou 545007, Guangxi, China.
Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160047.
J Environ Pathol Toxicol Oncol. 2018;37(1):15-25. doi: 10.1615/JEnvironPatholToxicolOncol.2018025223.
Hepatocellular carcinoma (HCC) has emerged as a prominent cancer in both developing and developed countries. Due to the increasing burden of HCC patients, massive resources are expended in their management. Furthermore, there is an urgent need to identify new molecular players that could be targeted to halt cancer development in the early phases. Noncoding RNAs (ncRNAs), which were previously thought to lack value, have the potential to play a pivotal role in the present era of personalized and translational research. Several recent studies have reported the involvement of ncRNAs in initiating, regulating, and nurturing HCC. This review provides insights regarding recently reports of noncoding RNAs and their diverse roles in initiation and development of hepatocellular carcinoma.
肝细胞癌(HCC)在发展中国家和发达国家都已成为一种突出的癌症。由于HCC患者的负担不断增加,在其治疗过程中耗费了大量资源。此外,迫切需要确定新的分子靶点,以便在癌症发展的早期阶段对其进行靶向治疗从而阻止癌症进展。非编码RNA(ncRNAs)曾被认为没有价值,而如今在个性化和转化研究时代,它们有可能发挥关键作用。最近的几项研究报告了ncRNAs在HCC的起始、调控和发展过程中的作用。本综述提供了关于非编码RNA的最新报道及其在肝细胞癌起始和发展中的多种作用的见解。