Laboratoire de biologie moléculaire parasitaire et fongique, faculté de médecine de Sfax, rue Magida-Boulila, 3029 Sfax, Tunisia.
Laboratoire de biologie moléculaire parasitaire et fongique, faculté de médecine de Sfax, rue Magida-Boulila, 3029 Sfax, Tunisia.
J Mycol Med. 2018 Sep;28(3):574-584. doi: 10.1016/j.mycmed.2018.04.011.
Fungal infections are a major cause of morbidity and mortality despite the latest developments of diagnostic tools and therapeutic options. Early initiation of the appropriate antifungal therapy has been demonstrated to have a direct impact on the patient's outcome. Antifungal susceptibility testing methods are available to detect antifungal resistance and to determine the best treatment for a specific fungus. American and European standards have been developed, as well as equivalent commercial systems, which are more appropriate for clinical laboratories. These studies have allowed the development of interpretative breakpoints against the most frequent agents of fungal infections in the world. Surveillance of antifungal susceptibility patterns can provide the local drug resistance data to the clinicians, which can further aid better management of patients. Antifungal susceptibility tests have become essential tools to identify resistance to antifungals, to know the local and global disease epidemiology and to guide the treatment of fungal diseases. The distribution of species and the prevalence of antifungal resistance in fungi isolates varied among different areas. Here we summarize the epidemiology of antifungal susceptibility pattern of different fungal species.
真菌感染是发病率和死亡率的主要原因，尽管诊断工具和治疗选择的最新进展。早期开始适当的抗真菌治疗已被证明对患者的预后有直接影响。抗真菌药敏试验方法可用于检测抗真菌耐药性，并确定针对特定真菌的最佳治疗方法。已经制定了美国和欧洲标准以及等效的商业系统，这些系统更适合临床实验室。这些研究允许针对世界上最常见的真菌感染病原体制定解释性折点。对抗真菌药物敏感性模式的监测可以为临床医生提供当地的耐药数据，这可以进一步帮助更好地管理患者。抗真菌药敏试验已成为识别抗真菌药物耐药性、了解当地和全球疾病流行病学以及指导真菌病治疗的重要工具。不同地区真菌分离株的种分布和抗真菌耐药性的流行情况有所不同。在这里，我们总结了不同真菌种属的抗真菌药敏模式的流行病学。
