Liu L, Gu Y, Li C, Zhang Q, Meng G, Wu H, Du H, Shi H, Xia Y, Guo X, Liu X, Bao X, Su Q, Fang L, Yu F, Yang H, Yu B, Sun S, Wang X, Zhou M, Jia Q, Guo Q, Song K, Huang G, Wang G, Niu K
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
J Hum Hypertens. 2017 Feb;31(2):116-120. doi: 10.1038/jhh.2016.48. Epub 2016 Jul 28.
Although the prevalence of prehypertension is rapidly increasing in China, the medical community has paid little attention to its prevention. Prior studies have demonstrated that uric acid directly contributes to vascular remodelling and endothelial dysfunction. However, few prospective studies have assessed the relationship between serum uric acid and prehypertension. We therefore designed a larger-scale cohort study to examine whether uric acid level is a predictive factor for developing prehypertension in adults. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. A prospective assessment (n=15 143) was performed. Participants without a history of hypertension or prehypertension were followed up for 2 to 6 years with a median follow-up duration of 2.8 years. Serum uric acid levels and blood pressure were assessed yearly during the follow-up. Adjusted Cox proportional hazards regression models were used to assess relationships between the quintiles of uric acid levels and the incidence of prehypertension. The incidence of prehypertension was 191 per 1000 person-years. In the final multivariate models, the hazard ratios (95% confidence interval) for prehypertension across uric acid quintiles were 1.00 (reference), 0.98 (0.90-1.07), 1.01 (0.93-1.10), 1.09 (1.001-1.20) and 1.17 (1.06-1.29) (P for trend <0.001), respectively. This population-based prospective cohort study has demonstrated that uric acid level is an independent predictor for developing prehypertension.
尽管在中国，高血压前期的患病率正在迅速上升，但医学界对其预防却很少关注。先前的研究表明，尿酸直接导致血管重塑和内皮功能障碍。然而，很少有前瞻性研究评估血清尿酸与高血压前期之间的关系。因此，我们设计了一项更大规模的队列研究，以检验尿酸水平是否是成年人发生高血压前期的预测因素。研究参与者来自天津医科大学总医院健康管理中心。进行了一项前瞻性评估（n = 15143）。对没有高血压或高血压前期病史的参与者进行了2至6年的随访，中位随访时间为2.8年。在随访期间每年评估血清尿酸水平和血压。使用调整后的Cox比例风险回归模型来评估尿酸水平五分位数与高血压前期发病率之间的关系。高血压前期的发病率为每1000人年191例。在最终的多变量模型中，尿酸五分位数组中高血压前期的风险比（95%置信区间）分别为1.00（参照）、0.98（0.90 - 1.07）、1.01（0.93 - 1.10）、1.09（1.001 - 1.20）和1.17（1.06 - 1.29）（趋势P<0.001）。这项基于人群的前瞻性队列研究表明，尿酸水平是发生高血压前期的独立预测因素。
