Department of Epidemiology and Biostatistics, School of Public Health , Wannan Medical College / Institute of Chronic Disease Prevention and Control , Wuhu - China.
Department of Clinical Nutrition , Hefei BOE Hospital , Hufei - China.
Arq Bras Cardiol. 2021 Jun;116(6):1072-1078. doi: 10.36660/abc.20200098.
Uric acid (UA), the end product of purine nucleotide metabolism, participates in the processes of metabolic and cardiovascular diseases. Experimental evidence suggests it is an important mediator in the physiological response to blood pressure increase.
To evaluate the association between serum UA levels and pre-hypertension and hypertension in a Chinese population.
A cross-sectional study was conducted from March to September 2017, and 1,138 participants aged 35 to 75 were enrolled in this study, where 223 normotensive, 316 pre-hypertensive, and 599 hypertensive subjects were selected to evaluate the association between serum UA levels and hypertension. A p-value <0.05 was considered statistically significant.
Serum UA levels were significantly higher in the pre-hypertension and hypertension group compared to the control group in the entire population (p<0.05 for all). Quantitative trait analysis indicated that serum UA levels were (2.92±0.81, 3.06±0.85, 3.22±0.98 mg/d) linearly increased in normotensive, pre-hypertensive and hypertensive females, with a p value of 0.008. Serum UA levels in the quartiles were positively correlated with DBP (p<0.05), particularly in females. After adjusting for age, gender, body mass index (BMI), glucose (GLU), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), the odds ratios (ORs) and 95% confidence intervals (CIs) of pre-hypertension from the lowest (referent) to the highest levels of serum UA were 1.718 (1.028-2.872), 1.018 (0.627-1.654) and 1.738 (1.003-3.010). Additionally, the second quartile of serum UA levels were significantly associated with hypertension, with an OR (95% CI) of 2.036 (1.256-3.298).
This study suggests that higher serum UA levels are positively associated with pre-hypertension and hypertension among Chinese adults.
尿酸（UA）是嘌呤核苷酸代谢的终产物，参与代谢和心血管疾病的过程。实验证据表明，它是对血压升高的生理反应的重要介质。
评估血清 UA 水平与中国人群中高血压前期和高血压之间的关系。
本研究采用横断面研究，于 2017 年 3 月至 9 月期间进行，共纳入 1138 名年龄在 35 至 75 岁之间的参与者，其中选择 223 名血压正常、316 名高血压前期和 599 名高血压患者来评估血清 UA 水平与高血压之间的关系。p 值<0.05 被认为具有统计学意义。
整个人群中，高血压前期和高血压组的血清 UA 水平明显高于对照组（所有 p<0.05）。定量特征分析表明，正常血压、高血压前期和高血压女性的血清 UA 水平分别呈（2.92±0.81、3.06±0.85、3.22±0.98）mg/d 的线性增加，p 值为 0.008。血清 UA 水平在四分位数上与舒张压（DBP）呈正相关（p<0.05），特别是在女性中。在校正年龄、性别、体重指数（BMI）、葡萄糖（GLU）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）后，血清 UA 水平从最低（参照）到最高水平的高血压前期的优势比（OR）和 95%置信区间（CI）分别为 1.718（1.028-2.872）、1.018（0.627-1.654）和 1.738（1.003-3.010）。此外，血清 UA 水平的第二四分位数与高血压显著相关，OR（95%CI）为 2.036（1.256-3.298）。
本研究表明，中国成年人中较高的血清 UA 水平与高血压前期和高血压呈正相关。
