外泌体介导的胃癌腹膜播散及其临床应用
Exosome-mediated peritoneal dissemination in gastric cancer and its clinical applications.
作者信息
Chen Kai-Bo, Chen Jian, Jin Xiao-Li, Huang Yi, Su Qiu-Ming, Chen Li
机构信息
Department of General Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China.
出版信息
Biomed Rep. 2018 Jun;8(6):503-509. doi: 10.3892/br.2018.1088. Epub 2018 Apr 19.
Abstract
The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell-cell communication. Gastric cancer tumor-derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial-to-mesenchymal transition, angiogenesis and chemoresistance. The present review focuses on previous studies addressing the exosome-dependent molecular transfer in peritoneal dissemination in gastric cancer and the potential clinical applications.
摘要
胃癌腹膜转移患者的预后较差，其潜在的分子机制仍不清楚。外泌体作为由蛋白质、核酸和脂质组成的大分子磷脂双分子层囊泡，充当细胞间通讯的介质。胃癌肿瘤来源的外泌体可能通过介导癌细胞与间皮细胞之间的相互作用参与腹膜转移的病理过程，从而导致肿瘤生长、迁移、黏附及侵袭能力增强、腹膜纤维化和细胞凋亡、间皮-间充质转化、血管生成及化疗耐药。本综述重点关注以往关于胃癌腹膜转移中外泌体依赖性分子转移及潜在临床应用的研究。
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