Boteon Yuri L, Afford Simon C, Mergental Hynek
1Liver Unit, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH UK.
2National Institute for Health Research, Birmingham Liver Biomedical Research Centre, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Curr Transplant Rep. 2018;5(2):113-120. doi: 10.1007/s40472-018-0188-7. Epub 2018 Mar 20.
Machine perfusion (MP) is a novel technology recently introduced in liver transplantation, redefining the current practice of organ preservation and pushing the limits of high-risk liver utilisation. This review highlights the key benefits of machine perfusion over conventional static cold storage (SCS), demonstrated in human liver research and clinical transplants.
The first clinical trials have demonstrated both safety and feasibility of MP. The most recent transplant series and result from a randomised trial suggest the technology is superior to SCS. The key benefits include extended period of organ preservation, decreased incidence of early allograft dysfunction and reduction of biliary complications. Normothermic liver perfusion allows viability testing to guide transplantability of the highest-risk organs. This technology also provides opportunities for therapeutic interventions to improve liver function and quality in organs that are currently declined for clinical use.
Machine perfusion is likely to transform the liver preservation pathway and to improve utilisation of high-risk grafts.
机器灌注（MP）是肝脏移植中最近引入的一项新技术，它重新定义了当前的器官保存方法，并突破了高风险肝脏利用的极限。本综述强调了在人类肝脏研究和临床移植中所证明的机器灌注相对于传统静态冷藏（SCS）的关键优势。
首批临床试验已证明机器灌注的安全性和可行性。最近的移植系列研究和一项随机试验的结果表明，该技术优于静态冷藏。其关键优势包括延长器官保存时间、降低早期移植物功能障碍的发生率以及减少胆道并发症。常温肝脏灌注允许进行活力测试，以指导最高风险器官的可移植性。该技术还为治疗干预提供了机会，以改善目前因临床使用而被拒绝的器官的肝功能和质量。
机器灌注可能会改变肝脏保存途径，并提高高风险移植物的利用率。
