Supportive Care Oncology Research Unit, Supportive Care Unit, Northeast Cancer Centre, Health Sciences North, 41 Ramsey Lake Road, Sudbury, ON, P3E 5J1, Canada.
Mariani and Associates, 208 Caswell Dr., Sudbury, ON, P3E 2N8, Canada.
Support Care Cancer. 2018 Nov;26(11):3801-3809. doi: 10.1007/s00520-018-4247-5. Epub 2018 May 17.
As developments in cancer treatment have improved outcomes, research has increasingly focused on the role of cancer-related cognitive impairment (CRCI) in quality of life for cancer survivors. Impairment profiles have been heterogeneous across studies, necessitating the study of these effects across different cohorts. The purpose of this preliminary study is to compare the memory profiles of Northeast Ontario breast and CNS cancer patients, as there is no literature which exists for profiling CRCI within this largely rural region.
Sixty-three outpatients with breast cancer (n = 32) or CNS tumors (n = 30) at the Northeast Cancer Centre in Sudbury, Canada, were administered a neuropsychological test battery as part of their clinical examination. Domains measured within this study included attention and concentration, processing speed, motor function, language skills, verbal and visual memory, and executive functioning.
Participants with brain tumors scored poorer on most neuropsychological measures than participants with breast cancer. Initial verbal memory for individuals with breast cancer was lower than delayed recall and recognition trials. Trial 1 performance for this group was also negatively correlated with self-reported anxiety scores.
Consistent with the literature, participants with breast cancer obtained higher scores on most test measures than participants with CNC tumors. Breast cancer participants had lower verbal memory scores on initial trials compared to delayed recall, potentially due to relationships with anxiety and attention. Further research into this cohort will strive to gain greater understanding of the patterns of deficits experienced and how these may inform individuals with cancer in other regions.
随着癌症治疗的发展提高了治疗效果，研究越来越关注癌症相关认知障碍（CRCI）对癌症幸存者生活质量的影响。研究表明，不同研究之间的认知障碍模式存在异质性，因此需要在不同队列中研究这些影响。本初步研究的目的是比较安大略省东北部乳腺癌和中枢神经系统（CNS）癌症患者的记忆模式，因为在这个以农村为主的地区，没有关于 CRCI 模式的文献。
加拿大萨德伯里东北癌症中心的 63 名门诊乳腺癌（n=32）或 CNS 肿瘤患者（n=30）作为研究对象，他们接受了神经心理学测试，作为其临床检查的一部分。该研究测量的领域包括注意力和集中力、处理速度、运动功能、语言技能、言语和视觉记忆以及执行功能。
与乳腺癌患者相比，脑肿瘤患者在大多数神经心理学测试中的得分较低。乳腺癌患者的初始言语记忆低于延迟回忆和识别测试。该组的试验 1 表现也与自我报告的焦虑评分呈负相关。
与文献一致，乳腺癌患者在大多数测试指标上的得分高于 CNS 肿瘤患者。与乳腺癌患者相比，在初始试验中，他们的言语记忆得分较低，这可能与焦虑和注意力有关。对该队列的进一步研究将努力更深入地了解患者经历的缺陷模式，以及这些模式如何为其他地区的癌症患者提供信息。
