客观测量的身体活动与大脑结构的关联：英国生物银行研究。

Association of objectively measured physical activity with brain structure: UK Biobank study.

机构信息

School Sport, Exercise & Health Sciences, Loughborough University, Loughborough, UK.

Department of Epidemiology and Public Health, University College London, London, UK.

出版信息

J Intern Med. 2018 Oct;284(4):439-443. doi: 10.1111/joim.12772. Epub 2018 Jun 7.

DOI:10.1111/joim.12772

PMID:29776014

Abstract

BACKGROUND

Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region.

METHODS

We used data from UK Biobank (n = 5272; aged 55.4 ± 7.5 years; 45.6% men) collected through 2013-2016. Participants wore the Axivity AX3 wrist-worn triaxial accelerometer for 7 days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain.

RESULTS

There was an association between physical activity (per SD increase) and grey matter volume after adjustment for a range of covariates, although this association was only detected in older adults (>60 years old). We also observed associations of physical activity with both left (B = 0.52, 95% CI, 0.01, 1.03; P = 0.046) and right hippocampal volume (B = 0.59, 95% CI, 0.08, 1.10; P = 0.024) in covariate-adjusted models.

CONCLUSION

In summary, physical activity may play a role in the prevention of neurodegenerative diseases.

摘要

背景

身体活动可能对认知有益，但机制尚不清楚。我们研究了身体活动与大脑体积之间的关联，重点关注海马体区域。

方法

我们使用了英国生物库（n = 5272；年龄 55.4 ± 7.5 岁；45.6%为男性）在 2013-2016 年收集的数据。参与者佩戴 Axivity AX3 三轴腕戴式加速度计，连续 7 天以评估习惯性身体活动。使用标准的 Siemens Skyra 3T 运行 VD13A SP4 进行结构磁共振成像，以获取大脑图像。

结果

在调整了一系列协变量后，身体活动（每增加一个标准差）与灰质体积之间存在关联，但这种关联仅在老年人（>60 岁）中检测到。我们还观察到身体活动与左（B = 0.52，95%CI，0.01，1.03；P = 0.046）和右海马体体积（B = 0.59，95%CI，0.08，1.10；P = 0.024）之间存在关联。