School Sport, Exercise & Health Sciences, Loughborough University, Loughborough, UK.
Department of Epidemiology and Public Health, University College London, London, UK.
J Intern Med. 2018 Oct;284(4):439-443. doi: 10.1111/joim.12772. Epub 2018 Jun 7.
Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region.
We used data from UK Biobank (n = 5272; aged 55.4 ± 7.5 years; 45.6% men) collected through 2013-2016. Participants wore the Axivity AX3 wrist-worn triaxial accelerometer for 7 days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain.
There was an association between physical activity (per SD increase) and grey matter volume after adjustment for a range of covariates, although this association was only detected in older adults (>60 years old). We also observed associations of physical activity with both left (B = 0.52, 95% CI, 0.01, 1.03; P = 0.046) and right hippocampal volume (B = 0.59, 95% CI, 0.08, 1.10; P = 0.024) in covariate-adjusted models.
In summary, physical activity may play a role in the prevention of neurodegenerative diseases.
身体活动可能对认知有益，但机制尚不清楚。我们研究了身体活动与大脑体积之间的关联，重点关注海马体区域。
我们使用了英国生物库（n = 5272；年龄 55.4 ± 7.5 岁；45.6%为男性）在 2013-2016 年收集的数据。参与者佩戴 Axivity AX3 三轴腕戴式加速度计，连续 7 天以评估习惯性身体活动。使用标准的 Siemens Skyra 3T 运行 VD13A SP4 进行结构磁共振成像，以获取大脑图像。
在调整了一系列协变量后，身体活动（每增加一个标准差）与灰质体积之间存在关联，但这种关联仅在老年人（>60 岁）中检测到。我们还观察到身体活动与左（B = 0.52，95%CI，0.01，1.03；P = 0.046）和右海马体体积（B = 0.59，95%CI，0.08，1.10；P = 0.024）之间存在关联。
总之，身体活动可能在预防神经退行性疾病方面发挥作用。
