Tateishi O, Aizawa O, Okamura T, Yoshida T, Furuhata H, Seo Y, Iinuma K, Shiki E
Fourth Department of Internal Medicine, Jikei University School of Medicine, Tokyo.
J Cardiol. 1988 Sep;18(3):601-9.
A newly-developed noninvasive method was used to measure left coronary blood flow during phantom experiments. Two techniques were used in which: (1) the sample position can always be set in a fluctuating vessel using a wall echo-tracking method with a phase-locked-loop, and (2) the Doppler reference signal was generated separately synchronous with the wall echo signal. These techniques were combined, using a commercially available pulsed Doppler apparatus (SSH-40B: Toshiba). Basic experiments were performed using a blood vessel phantom to verify the validity of these systems. Blood flow velocity in the fluctuating tube could be measured clearly using a vessel-tracking method. The blood flow velocity of the left anterior descending artery was measured in three normal subjects and in seven patients from the third intercostal space along the left sternal border. The velocity pattern was characterized by a crescendo-decrescendo shape in diastole. The peak velocity which appeared in diastole ranged from 19 to 69 cm/sec, with no difference by disease entity. However, in all cases, the blood flow velocity signals were marred by extraneous signals, making it impossible to measure blood flow velocity during systole. Further improvement of the system is mandatory in order to use this flowmeter clinically.
在模拟实验中,采用一种新开发的非侵入性方法来测量左冠状动脉血流量。使用了两种技术,其中:(1)采用带有锁相环的壁回声跟踪方法,可将样本位置始终设置在波动的血管中;(2)多普勒参考信号与壁回声信号同步单独生成。这些技术结合使用了市售的脉冲多普勒仪器(SSH - 40B:东芝)。使用血管模型进行基础实验以验证这些系统的有效性。使用血管跟踪方法可以清晰测量波动管中的血流速度。在三名正常受试者和七名患者中,从第三肋间沿左胸骨边缘测量左前降支动脉的血流速度。舒张期速度模式的特征为递增 - 递减形状。舒张期出现的峰值速度范围为19至69厘米/秒,不同疾病实体之间无差异。然而,在所有情况下,血流速度信号都受到外部信号干扰,导致无法在收缩期测量血流速度。为了在临床上使用这种流量计,必须对该系统进行进一步改进。