Department of Diagnostic Radiology, University of Iowa, Iowa City, IA 52242, USA; Department of Diagnostic & Interventional Radiology, Cairo University, Cairo, Egypt.
Department of Computer Science and Engineering, Pennsylvania State University, University Park, PA, USA.
Diagn Interv Imaging. 2018 Jun;99(6):349-359. doi: 10.1016/j.diii.2018.03.001. Epub 2018 May 18.
Diagnostic ultrasound has been clinically used for decades. More recently, high intensity focused ultrasound (HIFU) has been developed for therapeutic use as a non-invasive technique for tissue ablation. HIFU is also being investigated for advanced applications at the cellular level. Under guidance by magnetic resonance or ultrasound imaging, HIFU can achieve precise biological effects in tissue with a high safety profile. In this article, we discuss the basic principles, advantages and limitations of HIFU. We will also address the food and drug administration (FDA) approved clinical applications in the United States and highlight active HIFU research with promising clinical outcomes.
诊断超声已经在临床上应用了几十年。最近，高强度聚焦超声（HIFU）已被开发用于治疗，作为一种非侵入性的组织消融技术。HIFU 也在细胞水平的高级应用中进行研究。在磁共振或超声成像的引导下，HIFU 可以在组织中实现精确的生物学效应，具有很高的安全性。本文讨论了 HIFU 的基本原理、优点和局限性。我们还将介绍美国食品和药物管理局（FDA）批准的临床应用，并强调具有有前景的临床结果的活跃的 HIFU 研究。
