Milsom I, Hedner J, Hedner T
Department of Obstetrics and Gynecology, University of Göteborg, Sweden.
Acta Obstet Gynecol Scand. 1988;67(8):717-22. doi: 10.3109/00016349809004295.
Peripheral venous plasma concentrations of immunoreactive atrial natriuretic peptide (irANP) were studied longitudinally in 12 women at the 12th, 24th, and 36th week of pregnancy as well as 3-5 days and 3 months post partum. Serial measurements of maternal hemodynamics were performed simultaneously with blood sampling for irANP determination. With advancing pregnancy there were significant increases (p less than 0.001) in cardiac output, stroke volume and heart rate, while total peripheral vascular resistance decreased (p less than 0.001). All these changes were normalized 3 months post partum. Plasma irANP increased (p less than 0.05) from 23.2 +/- 1.3 pM/l at week 12 to 25.9 +/- 1.5 pM/l at week 36 of pregnancy, and fell significantly (p less than 0.01) to 20.5 +/- 1.1 pM/l 3 months post partum. Changes in plasma irANP appear to be related to changes in maternal central hemodynamics. The changes in ANP release probably represent one of several mechanisms that maintain circulatory and volume homeostasis during normal pregnancy.
对12名女性在妊娠第12周、24周和36周以及产后3 - 5天和3个月时，纵向研究了外周静脉血浆中免疫反应性心房利钠肽（irANP）的浓度。在采集血液样本测定irANP的同时，同步进行产妇血流动力学的系列测量。随着妊娠进展，心输出量、每搏输出量和心率显著增加（p<0.001），而总外周血管阻力降低（p<0.001）。所有这些变化在产后3个月恢复正常。血浆irANP从妊娠第12周时的23.2±1.3 pM/l增加（p<0.05）至妊娠第36周时的25.9±1.5 pM/l，并在产后3个月显著下降（p<0.01）至20.5±1.1 pM/l。血浆irANP的变化似乎与产妇中心血流动力学的变化有关。ANP释放的变化可能是正常妊娠期间维持循环和容量稳态的几种机制之一。
