Jansakul C, King R G, Boura A L, Brennecke S P, Handberg G M
Department of Pharmacology, Monash University, Victoria, Australia.
J Endocrinol. 1989 Jan;120(1):113-7. doi: 10.1677/joe.0.1200113.
Plasma concentrations of atrial natriuretic peptides (ANP) in female Wistar rats were measured by radioimmunoassay at oestrus, during pregnancy, during parturition and between 3 h and 4 days post partum. Concentrations of ANP in rats on days 10, 15 and 17 of pregnancy were not significantly different from those in non-pregnant animals in oestrus (32.5 +/- 2.2 pmol/l; mean +/- S.E.M., n = 9), but levels near term (days 20 and 21 of pregnancy) were reduced by approximately 50%. However, plasma concentrations of ANP at 6, 12 and 24 h post partum were approximately twice those of non-pregnant animals in oestrus, but returned to normal levels within 4 days after parturition. Maternal plasma volume increased significantly during pregnancy, and fell 15-20% 6-24 h post partum. These results suggest that the relationship between plasma volume and the plasma concentration of ANP is reset during pregnancy and changes rapidly post partum. The results do not necessarily, however, imply any changes in the relationship between atrial pressure and the concentration of ANP.
采用放射免疫分析法测定雌性Wistar大鼠在发情期、妊娠期、分娩期以及产后3小时至4天期间血浆中心房利钠肽（ANP）的浓度。妊娠第10、15和17天大鼠的ANP浓度与处于发情期的未孕动物相比无显著差异（32.5±2.2 pmol/L；平均值±标准误，n = 9），但接近足月时（妊娠第20和21天）浓度降低约50%。然而，产后6、12和24小时血浆ANP浓度约为处于发情期的未孕动物的两倍，但产后4天内恢复至正常水平。孕期母体血容量显著增加，产后6 - 24小时下降15 - 20%。这些结果表明，孕期血浆容量与血浆ANP浓度之间的关系重新设定，产后迅速变化。然而，这些结果并不一定意味着心房压力与ANP浓度之间的关系有任何变化。
