RINN22关于精准营养和营养组学的指南与立场。
Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics.
作者信息
Ramos-Lopez Omar, Assmann Taís Silveira, Astudillo Muñoz Elcy Yaned, Baquerizo-Sedano Luis, Barrón-Cabrera Elisa, Bernal Claudio Adrián, Bressan Josefina, Cuevas-Sierra Amanda, Dávalos Alberto, De la Cruz-Mosso Ulises, De la Garza Ana Laura, De Luis Daniel A, Díaz de la Garza Rocío I, Dos Santos Karina, Fernández-Condori Roxana Carla, Fernández-Quintela Alfredo, Garcia Diaz Diego F, Gonzalez-Becerra Karina, Lopes Rosado Eliane, López de Las Hazas María-Carmen, Marín Alejandre Bertha Araceli, Angel Martin Alberto, Martinez-Lopez Erika, Martínez-Urbistondo Diego, Milagro Fermin I, Hermsdorff Helen Hermana M, Muguerza Begoña, Nicoletti Carolina F, Obregón Rivas Ana Maria, Parra-Rojas Isela, Portillo Maria Puy, Santos José L, Steemburgo Thais, Tejero Maria Elizabeth, Terán Anny Cristina, Treviño Victor, Vizmanos Bárbara, Martinez J Alfredo
机构信息
Medicine and Psychology School, Autonomous University of Baja California, Tijuana, Mexico.
Graduate Program in Medical Sciences, Endocrinology, Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
出版信息
Lifestyle Genom. 2025;18(1):1-19. doi: 10.1159/000542789. Epub 2024 Nov 30.
BACKGROUND
Precision nutrition is based on the integration of individual's phenotypical and biological characteristics including genetic variants, epigenetic marks, gut microbiota profiles, and metabolite fingerprints as well as medical history, lifestyle practices, and environmental and cultural factors. Thus, nutriomics areas including nutrigenomics, nutrigenetics, nutriepigenetics, nutrimetabolomics, and nutrimetagenomics have emerged to comprehensively understand the complex interactions between nutrients, diet, and the human body's molecular processes through precision nutrition.
SUMMARY
This document from the Ibero-American Network of Nutriomics and Precision Nutrition (RINN22;
KEY MESSAGES
The progress and participation of nutriomics to precision nutrition is an essential pillar for addressing diet-related diseases and developing innovative managing strategies, which will be promoted by advances in bioinformatics, machine learning, and integrative software, as well as the description of specific novel biomarkers. In this context, synthesizing and critically evaluating the latest developments, potential applications, and future needs in the field of nutrition is necessary with a holistic perspective, incorporating progress in omics technologies aimed at precision nutrition interventions. This approach must address and confront healthy, social, food security, physically active lifestyle, sanitation, and sustainability challenges with preventive, participatory, and predictive strategies of personalized, population, and planetary nutrition for a precision tailored health.
背景
精准营养基于个体的表型和生物学特征的整合，包括基因变异、表观遗传标记、肠道微生物群谱和代谢物指纹，以及病史、生活方式、环境和文化因素。因此，营养组学领域，包括营养基因组学、营养遗传学、营养表观遗传学、营养代谢组学和营养元基因组学应运而生，旨在通过精准营养全面了解营养素、饮食与人体分子过程之间的复杂相互作用。
总结
这份来自伊比利亚 - 美洲营养组学与精准营养网络（RINN22；https://rinn22.com/）的文件全面概述了精准营养方法的概念，以指导其在临床和公共卫生中的应用，并确立RINN22在精准营养当前和未来状况方面的立场。
关键信息
营养组学对精准营养的进展和参与是应对与饮食相关疾病和制定创新管理策略的重要支柱，这将通过生物信息学、机器学习和整合软件的进步以及特定新型生物标志物的描述来推动。在这种背景下，有必要从整体角度综合并批判性地评估营养领域的最新发展、潜在应用和未来需求，纳入旨在进行精准营养干预的组学技术进展。这种方法必须通过个性化、群体和行星营养的预防、参与和预测策略，以精准定制健康的方式应对和面对健康、社会、食品安全、积极的生活方式、卫生和可持续性挑战。
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