与年龄相关的脑部疾病和衰老过程中蛋白质羰基化、硝化和氯化的起源及病理生理学
Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging.
作者信息
Gonos Efstathios S, Kapetanou Marianna, Sereikaite Jolanta, Bartosz Grzegorz, Naparło Katarzyna, Grzesik Michalina, Sadowska-Bartosz Izabela
机构信息
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens 11635, Greece.
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens 15701, Greece.
出版信息
Aging (Albany NY). 2018 May 17;10(5):868-901. doi: 10.18632/aging.101450.
Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
非酶促蛋白质修饰在所有生命系统中都会不可避免地发生。此类修饰的产物在细胞和生物体衰老过程中会不断积累，并可能导致与其年龄相关的功能衰退。本文综述了不可逆蛋白质修饰的形成，如羰基化、硝化和氯化、4-羟基壬烯醛修饰、修饰蛋白质的清除以及这些蛋白质修饰在人类和模式生物衰老过程中的积累，以及它们在与年龄相关的脑部疾病中的累积增加。
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