Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Department of Pharmacology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
J Cancer Res Clin Oncol. 2018 Aug;144(8):1547-1559. doi: 10.1007/s00432-018-2670-0. Epub 2018 May 19.
Quality-of-life (QOL) has been reported to affect the prognosis of many types of cancer, and several studies used various QOL assessment tools to determine the relationship between QOL and cancer prognosis. In this study, QOL-Questionnaire for Cancer Patients Treated with Anti-Cancer Drugs-the Breast (QOL-ACD-B) was modified to be suitable for preoperative chemotherapy (POC) and was named the QOL-ACD-BP.
A total of 300 patients were treated with POC after being diagnosed with breast cancer between February 2007 and December 2016 at our institute. We evaluated novel evaluation scale for QOL (QOL-ACD-BP) before and after POC in a retrospective manner.
In the multivariate analysis with overall survival, the high QOL before [p = 0.048, hazard ratio (HR) 0.441] or after POC (p = 0.030, HR 0.273) was an independent factor.
Our study shows that QOL after POC may also affect prognosis and supported the importance of maintaining QOL in cancer treatment. In patients with breast cancer treated with POC, QOL-ACD-BP, which is a new QOL evaluation index, was found to be a useful tool for predicting the patients' prognosis.
生活质量（QOL）已被报道会影响多种癌症的预后，有几项研究使用了各种 QOL 评估工具来确定 QOL 与癌症预后之间的关系。在本研究中，对癌症患者抗癌药物治疗生活质量问卷-乳房（QOL-ACD-B）进行了改良，使其适用于术前化疗（POC），并将其命名为 QOL-ACD-BP。
2007 年 2 月至 2016 年 12 月期间，我院对 300 例确诊为乳腺癌的患者进行了 POC 治疗。我们回顾性地评估了新的 QOL 评估量表（QOL-ACD-BP）在 POC 前后的变化。
在总生存的多变量分析中，POC 前[P=0.048，风险比（HR）0.441]或 POC 后[P=0.030，HR 0.273]高 QOL 是独立的影响因素。
我们的研究表明，POC 后的 QOL 也可能影响预后，并支持在癌症治疗中保持 QOL 的重要性。在接受 POC 治疗的乳腺癌患者中，QOL-ACD-BP 是一种新的 QOL 评估指标，被发现是预测患者预后的有用工具。
